Abstract | BACKGROUND: OBJECTIVES: METHODS: Fifteen formaldehyde-allergic individuals and a control group of 12 individuals without contact allergy to formaldehyde and formaldehyde releasers were included in the study. The individuals performed the repeated open application test (ROAT) during 4 weeks with four different moisturizers releasing formaldehyde in concentrations that had been determined as > 40, 20-40, 2·5-10 and 0 p.p.m. by the chromotropic acid (CA) spot test. Dimethyloldimethylhydantoin was used as a formaldehyde releaser in the moisturizers. The ROAT was performed on areas of experimentally induced sodium lauryl sulfate dermatitis. The study was double blind, controlled and randomized. RESULTS: Nine of the 15 formaldehyde-allergic individuals had reappearance or worsening of dermatitis on the areas that were treated with moisturizers containing formaldehyde. No such reactions were observed in the control group (P < 0·001) or for the moisturizers without formaldehyde in the formaldehyde-allergic individuals (P < 0·001). CONCLUSIONS: Our results demonstrate that the low concentrations of formaldehyde often found in skincare products by the CA method are sufficient to worsen an existing dermatitis in formaldehyde-allergic individuals.
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Authors | I Hauksson, A Pontén, B Gruvberger, M Isaksson, M Engfeldt, M Bruze |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 174
Issue 2
Pg. 371-9
(Feb 2016)
ISSN: 1365-2133 [Electronic] England |
PMID | 26480304
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 British Association of Dermatologists. |
Chemical References |
- Cosmetics
- Naphthalenesulfonates
- Preservatives, Pharmaceutical
- Formaldehyde
- chromotropic acid
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Topics |
- Adult
- Aged
- Colorimetry
(methods)
- Cosmetics
(adverse effects, chemistry)
- Dermatitis, Irritant
(etiology)
- Double-Blind Method
- Drug Hypersensitivity
(etiology)
- Female
- Formaldehyde
(adverse effects, analysis)
- Humans
- Male
- Middle Aged
- Naphthalenesulfonates
(metabolism)
- Patch Tests
- Preservatives, Pharmaceutical
(adverse effects, analysis)
- Skin Care
(adverse effects)
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