Abstract | OBJECTIVE: DESIGN: Observational study nested within a large prospective study using multivariable linear regression to model circulating insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 with acute and chronic clinical variables, and genotype from five polymorphisms in insulin-like growth factor pathway genes. SETTING: ICUs from two large academic medical centers. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Total insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 were measured in plasma using IMMULITE assays (Siemens, Malvern, PA). We examined age, gender, body mass index, cirrhosis, and diabetes, as well as Acute Physiology, Age, and Chronic Health Evaluation III score, acute hepatic dysfunction, pneumonia and aspiration, sepsis/ septic shock, acute respiratory distress syndrome, and receipt of corticosteroids. Body mass index, cirrhosis, and acute respiratory distress syndrome were strongly associated with insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 levels; Acute Physiology, Age, and Chronic Health Evaluation III was strongly associated with insulin-like growth factor-1 levels; and age was strongly associated with insulin-like growth factor-binding protein-3. Five polymorphisms (IGF1: rs1520220, rs35767, rs2946834; IGFBP1: rs4619; IGFBP3: rs2854746) were analyzed for associations with plasma levels. When genotypes were added to models, rs2854746 was significantly associated with plasma insulin-like growth factor-binding protein-3. Genotype explained an additional 2% of variability with an overall adjusted R-square of 0.18. CONCLUSIONS:
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Authors | Amy M Ahasic, Paula Tejera, Yongyue Wei, Li Su, Christos S Mantzoros, Ednan K Bajwa, B Taylor Thompson, David C Christiani |
Journal | Critical care medicine
(Crit Care Med)
Vol. 43
Issue 12
Pg. 2651-9
(Dec 2015)
ISSN: 1530-0293 [Electronic] United States |
PMID | 26427594
(Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
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Topics |
- APACHE
- Academic Medical Centers
- Acute Disease
- Age Factors
- Aged
- Aged, 80 and over
- Body Mass Index
- Chronic Disease
- Critical Illness
- Female
- Genotype
- Humans
- Insulin-Like Growth Factor Binding Protein 3
(blood, genetics)
- Insulin-Like Growth Factor I
(analysis, genetics)
- Intensive Care Units
(statistics & numerical data)
- Linear Models
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Prospective Studies
- Risk Factors
- Sex Factors
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