Abstract | OBJECTIVE: METHODS: We analyzed the composition of immune cell subsets and the activation level of monocytes by flow cytometry and the response against viral and vaccine antigens by ELISpot. RESULTS: None of the endpoints measured revealed any immunosuppressive effect of the therapeutic antibody. Activation of monocytes slightly decreased during treatment as predicted by the hypothesized mechanism of action of GNbAC1. CONCLUSION: These results support the conclusion that the antibody is safe for use in patients with MS. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that in patients with MS GNbAC1 does not significantly affect several biomarkers of systemic immune response.
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Authors | Maria Zimmermann, Nicholas S R Sanderson, Maria Rasenack, Patrice H Lalive, Alois B Lang, Francois Curtin, Raija L P Lindberg, Ludwig Kappos, Tobias Derfuss |
Journal | Neurology(R) neuroimmunology & neuroinflammation
(Neurol Neuroimmunol Neuroinflamm)
Vol. 2
Issue 5
Pg. e144
(Oct 2015)
ISSN: 2332-7812 [Print] United States |
PMID | 26380353
(Publication Type: Journal Article)
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