Photoinduced cytotoxicity by a platinum diimine complex employing magnetite-silica nanocomposites as delivery vehicles.

Abstract

Tartaric acid-modified core-shell magnetite-silica nanocomposites were prepared by a sol-gel method, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy and dynamic light scattering. Then the nanocomposites were employed as carriers of a photoactive platinum diimine complex. Photoinduced cytotoxicity by the photosensitizer-loaded nanocomposites in different human carcinoma cells has been studied by cell viability assay. The results suggest that the as-synthesized nanocomposites have good stability in water, and the cytotoxicity induced by the platinum diimine complex in red light can be significantly enhanced when the photosensitizer is loaded with the magnetic nanocomposites.

• Authors: Zhigang Zhang, Haisha Li, Ruihui Dai, Aiyun Chai
• Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (Biometals) Vol. 28 Issue 5 Pg. 945-50 (Oct 2015) ISSN: 1572-8773 [Electronic] Netherlands
• PMID: 26315847 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Photosensitizing Agents
• Tartrates
• Platinum
• Silicon Dioxide
• tartaric acid
• Ferrosoferric Oxide

Topics

• Carcinoma (drug therapy)
• Cell Line, Tumor
• Drug Delivery Systems
• Dynamic Light Scattering
• Ferrosoferric Oxide (administration & dosage, chemistry)
• Humans
• Light
• Microscopy, Electron, Transmission
• Nanocomposites (administration & dosage, chemistry)
• Photosensitizing Agents
• Platinum (administration & dosage, chemistry)
• Silicon Dioxide (administration & dosage, chemistry)
• Spectroscopy, Fourier Transform Infrared
• Tartrates (chemistry)
• X-Ray Diffraction