Abstract | BACKGROUND AND RATIONALE: MATERIAL AND METHODS: All had anthropometric and plasma biochemical measurements, FL and AVF assessments by computed tomography. RESULTS: The FL prevalence was 35.6% in men and 28.0% in women, p < 0.01. The prevalence of obesity, metabolic syndrome and homeostasis model assessment of insulin resistance (HOMA-IR) was significantly higher in FL compared to non FL subjects. FL and AVF accounted for 21 and 17%, respectively, to hs-CRP plasma levels. FL, AVF ≥ P75 and HOMA-IR ≥ P75 were independently and additively associated with plasma hs-CRP. The risk of hs-CRP ≥ 3 mg/L increased progressively in men from 1.36 (0.5-3.86) through 3.58 (1.32-9.7) in those with 1 or 3 factors respectively. In women from 2.25 (1.2-4.2) to 4.67 (2.3-9.4), respectively. In conclusion, both the FL and hs-CRP ≥ 3 mg/L occur in 1 of every 3 non CAD subjects. In men, FL and AVF ≥ P75 were associated with 3.6 times the risk of hs-CRP ≥ 3 mg/L, while in women, these factors were independently and additively associated with a 4.7 times higher risk of systemic inflammation.
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Authors | Guillermo C Cardoso-Saldaña, Aida X Medina-Urrutia, Carlos Posadas-Romero, Juan G Juárez-Rojas, Esteban Jorge-Galarza, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez |
Journal | Annals of hepatology
(Ann Hepatol)
2015 Sep-Oct
Vol. 14
Issue 5
Pg. 658-65
ISSN: 1665-2681 [Print] Mexico |
PMID | 26256894
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Inflammation Mediators
- C-Reactive Protein
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Topics |
- Abdominal Fat
(metabolism, physiopathology)
- Adiposity
- Adult
- Aged
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Cross-Sectional Studies
- Fatty Liver
(blood, diagnosis, epidemiology, physiopathology)
- Female
- Humans
- Inflammation
(blood, diagnosis, epidemiology)
- Inflammation Mediators
(blood)
- Insulin Resistance
- Male
- Mexico
(epidemiology)
- Middle Aged
- Obesity, Abdominal
(blood, diagnosis, epidemiology, physiopathology)
- Prevalence
- Risk Factors
- Sex Factors
- Tomography, X-Ray Computed
- Up-Regulation
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