Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial.

Abstract

BACKGROUND:

The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.

METHODS:

Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type 2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3-months and 6 months.

RESULTS:

At 6 months, Group 2 had greater mean reduction (4.73 mm) in PD as compared to Group 1 (2.09 mm; p < 0.05) and also a greater mean CAL gain (3.92 mm versus 1.64 mm; p < 0.05).

CONCLUSION:

The use of 3% SZ gel, when used as an adjunct to non-surgical periodontal therapy in subjects with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.

• Authors: N Priyanka, Nitish Kalra, Shahab Saquib, Shahabe Saquib, Nikhil Malgaonkar, Malgaonkar Nikhil, Bassel Tarakji, Jadhav Varsha, Davangere Umashree, A R Pradeep
• Journal: Journal of the International Academy of Periodontology (J Int Acad Periodontol) Vol. 17 Issue 2 Pg. 42-8 (Apr 2015) ISSN: 1466-2094 [Print] England
• PMID: 26242010 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Gels
• Nitroimidazoles
• Placebos
• satranidazole

Topics

• Administration, Topical
• Adult
• Anti-Bacterial Agents (administration & dosage, analysis)
• Chronic Periodontitis (drug therapy)
• Combined Modality Therapy
• Dental Plaque Index
• Dental Scaling (methods)
• Diabetes Mellitus, Type 2 (complications)
• Double-Blind Method
• Female
• Follow-Up Studies
• Gels
• Gingival Crevicular Fluid (chemistry)
• Humans
• Male
• Middle Aged
• Nitroimidazoles (administration & dosage, analysis)
• Periodontal Attachment Loss (drug therapy)
• Periodontal Index
• Periodontal Pocket (drug therapy)
• Placebos
• Root Planing (methods)
• Treatment Outcome