Acute Liver Failure Due to Regorafenib May Be Caused by Impaired Liver Blood Flow: A Case Report.

Abstract

BACKGROUND/AIM:

Regorafenib has been approved for treatment of patients with unresectable or recurrent gastrointestinal stromal tumors resistant to imatinib or sunitinib. However, regorafenib has severe side-effects, including acute liver failure. We describe the case of a patient with multiple liver metastases of a small intestinal stromal tumor who experienced acute liver failure while being treated with regorafenib.

CASE REPORT:

A 50-year-old patient with an unresectable small intestinal stromal tumor resistant to prior treatment with imatinib and sunitinib was started on regorafenib, but experienced acute liver failure 10 days later. Plasma exchange and steroid pulse treatment improved her liver function. During liver failure, abdominal ultrasonography showed to-and-fro flow in the portal vein. Lactate dehydrogenase concentration was markedly elevated to 1633 U/l. These findings indicate that liver failure in this patient was due to impaired liver blood flow.

CONCLUSION:

Regorafenib may impair liver blood flow, inducing acute liver failure.

• Authors: Takaki Akamine, Koji Ando, Eiji Oki, Hiroshi Saeki, Yuichiro Nakashima, Y U Imamura, Kippei Ohgaki, Yoshihiko Maehara
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 7 Pg. 4037-41 (Jul 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26124352 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Antineoplastic Agents
• Phenylurea Compounds
• Pyridines
• regorafenib

Topics

• Antineoplastic Agents (adverse effects, therapeutic use)
• Female
• Humans
• Intestinal Neoplasms (drug therapy)
• Liver Failure, Acute (chemically induced)
• Middle Aged
• Phenylurea Compounds (adverse effects, therapeutic use)
• Pyridines (adverse effects, therapeutic use)
• Regional Blood Flow (drug effects)