Abstract | OBJECTIVES: The objective of this study was to compare the effects of ketamine and alfaxalone on the application of a validated feline-specific multidimensional composite pain scale (UNESP-Botucatu MCPS). METHODS: RESULTS: Psychomotor scores were higher with ketamine at hours 1 (3.5 [0-5.0], P <0.0001), 2 (2.5 [0-4.0], P <0.0001) and 3 (0.5 [0-4.0], P = 0.009) post-extubation compared with alfaxalone (hour 1, 0 [0-2]; hour 2, 0 [0-0]; hour 3, 0 [0-0]). Six cats in the ketamine group crossed the analgesic intervention threshold. In contrast, pain expression scores did not differ significantly between treatments at any time (P >0.05); one cat from each group crossed the analgesic intervention threshold. Sedation was greater with ketamine (1 [0-3], P = 0.02) than alfaxalone (0 [0-1]) 1 h post-extubation. No cats had visible inflammation at the injection sites at any time. CONCLUSIONS AND RELEVANCE:
Ketamine has a confounding effect on the psychomotor subscale of the pain scale studied, which may lead to erroneous administration of rescue analgesia. In contrast, alfaxalone was not associated with significant increases in either pain subscale. These effects of ketamine should be considered when evaluating acute postoperative pain in cats.
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Authors | Mandy Buisman, Marika C Wagner, Michelle Mm Hasiuk, Melanie Prebble, Laura Law, Daniel Sj Pang |
Journal | Journal of feline medicine and surgery
(J Feline Med Surg)
Vol. 18
Issue 8
Pg. 643-51
(08 2016)
ISSN: 1532-2750 [Electronic] England |
PMID | 26088567
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © The Author(s) 2015. |
Chemical References |
- Analgesics, Non-Narcotic
- Anesthetics
- Pregnanediones
- Dexmedetomidine
- Ketamine
- alphaxalone
- Hydromorphone
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Topics |
- Analgesics, Non-Narcotic
(administration & dosage)
- Anesthesia, General
(methods, veterinary)
- Anesthetics
(administration & dosage)
- Animals
- Behavior, Animal
(drug effects)
- Cats
- Dexmedetomidine
(administration & dosage)
- Hydromorphone
(administration & dosage)
- Ketamine
(administration & dosage)
- Pain Management
(methods, veterinary)
- Pain Measurement
(veterinary)
- Pregnanediones
(administration & dosage)
- Prospective Studies
- Psychomotor Performance
(drug effects)
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