Abstract | BACKGROUND AND AIMS: METHODS: Animals were divided into four groups with ten animals each. Rats of three groups received dextran sodium sulfate to induce colitis and animals of two of these groups received 5 mg iron/kg of body weight a day, as ferrous sulfate or iron polymaltose complex, for 7 days. Gross colon anatomy, histology of colon and liver, stainings of L-ferritin, Prussian blue, hepcidin, tumor necrosis factor-α, and interleukin-6, as well serum levels of liver enzymes, inflammatory markers, and iron markers, were assessed. RESULTS: CONCLUSION:
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Authors | Jorge E Toblli, Gabriel Cao, Margarita Angerosa |
Journal | Drug design, development and therapy
(Drug Des Devel Ther)
Vol. 9
Pg. 2585-97
( 2015)
ISSN: 1177-8881 [Electronic] New Zealand |
PMID | 26005335
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ferric Compounds
- Ferrous Compounds
- Hematinics
- ferrous sulfate
- Dextran Sulfate
- teferrol
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Topics |
- Administration, Oral
- Animals
- Colitis
(chemically induced, pathology)
- Dextran Sulfate
(toxicity)
- Disease Models, Animal
- Female
- Ferric Compounds
(administration & dosage, toxicity)
- Ferrous Compounds
(administration & dosage, toxicity)
- Hematinics
(administration & dosage, toxicity)
- Inflammation
(chemically induced, pathology)
- Male
- Oxidative Stress
(drug effects)
- Rats
- Rats, Sprague-Dawley
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