Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients.

Abstract

INTRODUCTION:

This study aimed to analyze the characteristics of HBsAg, HBsAb, coexistence of HBsAg and HBsAb, and the genotypic distribution of HBV in Chinese schizophrenia patients.

METHODOLOGY:

A total of 1,694 schizophrenia patients, 9-85 years of age, were recruited for the present study. HBsAg, HBsAb, and HBV DNA were detected with commercial methods. ALT, AST, γ-GT, TBIL, and IBIL were measured by an automatic biochemistry analyzer. All statistical analyses were performed with SPSS 13.0.

RESULTS:

The seroprevalence of HBsAg and HBsAb in 1,649 schizophrenia patients was 11.0% and 54.6%, respectively. HBsAb seroprevalence significantly decreased with the duration of the disease (p = 0.0009). The lowest seroprevalence of HBsAg was determined in 9.4% of the patients who had had the illness for < 1 year, and then increased to 11.7%, 11.3% and 11.7% in the patients who had had the illness for 1-5 years, 6-10 years and > 10 years. HBsAg and HBsAb coexisted in 69 individuals, which comprised 4.2% of the total subjects, and in 38.1% of the HBsAg-positive patients. Additionally, HBV titers were quantified in 64 HBsAg-positive samples; the highest virus titer was 6.14×108 copies/mL, while 12 patients had less than 500 copies/mL. Moreover, among 48 HBV strains isolated from 62 HBsAg-positive samples, 33 and 15 strains belonged to genotypes C and B, respectively.

CONCLUSION:

Genotypes B and C HBV were the dominant genotypes distributed in schizophrenia patients, and the HBsAb seroprevalence significantly decreased with illness duration. Effective prevention strategies for against HBV transmission are required.

• Authors: Huijuan Zhu, Xingxiang Liu, Yong Xue, Chong Shen, Yinghui Li, Aili Wang, Yi Ding, Zhi Zheng, Chen Dong
• Journal: Journal of infection in developing countries (J Infect Dev Ctries) Vol. 9 Issue 5 Pg. 512-8 (May 18 2015) ISSN: 1972-2680 [Electronic] Italy
• PMID: 25989171 (Publication Type: Journal Article)

Chemical References

• DNA, Viral
• Enzymes
• Hepatitis B Antibodies
• Hepatitis B Surface Antigens

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• China (epidemiology)
• DNA, Viral (genetics, isolation & purification)
• Enzymes (blood)
• Female
• Genotype
• Hepatitis B (epidemiology, immunology, pathology, virology)
• Hepatitis B Antibodies (blood)
• Hepatitis B Surface Antigens (blood)
• Hepatitis B virus (classification, genetics, isolation & purification)
• Humans
• Male
• Middle Aged
• Schizophrenia (complications)
• Seroepidemiologic Studies
• Young Adult