Long-term sequelae treatment of peripheral facial paralysis with botulinum toxin type A: Repartition and kinetics of doses used.

Abstract

STUDY OBJECTIVES:

Botulinum toxin is a key therapeutic tool in the comprehensive treatment of peripheral facial paralysis. It fights spasms, synkinesis and overactivity of the different skin muscles responsible of facial expressions. Even though injection techniques as well as target muscles have been well identified, doses used remain quite imprecise and often not detailed muscle by muscle, further more dosage progression has not been monitored over time. Our retrospective study is the first one to refine the repartition of botulinum toxin doses on each of the relevant skin muscles and assess dosage kinetics.

PATIENTS AND METHODS:

Thirty patients were included since 2008 with a mean follow-up of 2.3years. Each patient had at least 3 injections, with a delay of 4 to 6months between each injection.

RESULTS:

Mean doses are indicated for each muscle injected on the paralyzed and healthy sides. Dose kinetics suggests an initial dosage increase after the first injection followed by a decrease over time. No treatment resistance was observed.

CONCLUSION:

Our study represents a didactic help in using botulinum toxin for sequelae of peripheral facial paralysis by providing more details on the effective mean doses for each muscle and their progression over time.

• Authors: M Risoud, N Aljudaibi, V Duquennoy-Martinot, P Guerreschi
• Journal: Annales de chirurgie plastique et esthetique (Ann Chir Plast Esthet) Vol. 61 Issue 1 Pg. 10-5 (Feb 2016) ISSN: 1768-319X [Electronic] France
• PMID: 25953657 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Botulinum Toxins, Type A

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Animals
• Botulinum Toxins, Type A (administration & dosage, pharmacokinetics)
• Child
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Facial Muscles (drug effects)
• Facial Paralysis (drug therapy, etiology)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Rats
• Retrospective Studies
• Treatment Outcome