Abstract | BACKGROUND: METHODS:
Opioid-using persons enrolled in a community-recruited cohort in Vancouver, Canada, were asked whether or not they would be willing to take XR-NTX. Logistic regression was used to independently identify factors associated with willingness to take the medication. RESULTS: Among the 657 participants surveyed between June 1, 2013, and November 30, 2013, 342 (52.1%) were willing to take XR-NTX. One factor positively associated with willingness was daily heroin injection (adjusted odds ratio [AOR] = 1.53; 95% confidence interval [CI] = 1.02-2.31), whereas Caucasian ethnicity was negatively associated (AOR = 0.59; 95% CI = 0.43-0.82). Satisfaction with agonist therapy (13.4%) and unwillingness to stop opioids being used for pain (26.9%) were the most common reasons for being unwilling to take XR-NTX. CONCLUSIONS: A high level of willingness to take XR-NTX was observed in this setting. Interestingly, daily injection heroin use was positively associated with willingness, whereas Caucasian participants were less willing to take XR-NTX. Although explanations for unwillingness were described in this study, further research is needed to investigate real-world acceptability of XR-NTX as an additional option for the treatment of opioid use disorder.
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Authors | Keith Ahamad, M J Milloy, Paul Nguyen, Sasha Uhlmann, Cheyenne Johnson, Todd P Korthuis, Thomas Kerr, Evan Wood |
Journal | Addiction science & clinical practice
(Addict Sci Clin Pract)
Vol. 10
Pg. 12
(May 03 2015)
ISSN: 1940-0640 [Electronic] England |
PMID | 25935714
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Delayed-Action Preparations
- Narcotic Antagonists
- Naltrexone
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Topics |
- Adult
- Canada
- Delayed-Action Preparations
- Female
- Humans
- Injections, Intramuscular
- Male
- Middle Aged
- Naltrexone
(administration & dosage, therapeutic use)
- Narcotic Antagonists
(administration & dosage, therapeutic use)
- Opioid-Related Disorders
(drug therapy, psychology)
- Patient Acceptance of Health Care
(psychology)
- Socioeconomic Factors
- Substance Abuse, Intravenous
(drug therapy, psychology)
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