Impact of administration of folic acid on selected indicators of inflammation in patients with primary arterial hypertension.

Abstract

The results of epidemiological and clinical tests have shown that in patients with primary arterial hypertension, a chronic mild inflammation develops. The purpose of the study was to determine whether administration of folic acid to patients with primary arterial hypertension influences concentrations of indicators of inflammation: hsCRP, sICAM-1 and sVCAM-1.

MATERIAL AND METHODS:

The examination was carried out in 41 patients with primary arterial hypertension, aged 19-65 (21 men and 20 women), without complications of hypertension and/or coexisting diseases. The examined patients were administered 15 mg of folic acid once a day for 45 days. Before and after administration of folic acid, concentrations of folic acid, homocysteine, hsCRP, sICAM-1 and sVCAM-1 in serum were assessed. Concentrations of folic acid and homocysteine were determined using the immunoenzymatic method (Abbott) on an AxSYM analyzer. The level of C-reactive protein (CRP) was determined with an ultra-sensitive turbidimetric assay on a Dimension analyzer (Siemens). Next, concentrations of adhesion particles sICAM-1 and sVCAM-1 were assessed with the ELISA technique (R&D).

RESULTS:

After the administration of folic acid in patients with primary arterial hypertension, a significant decrease in median concentrations of homocysteine in blood was observed. Simultaneously, the median hsCRP, ICAM-1 and VCAM-1 concentrations in serum in patients with primary arterial hypertension were significantly reduced.

CONSLUSIONS:

Administration of folic acid to persons with primary arterial hypertension in a dose of 15 mg/ day for 45 days caused a decrease in the concentration of homocysteine in serum. That could indirectly result in the decrease in concentrations of the indicators of inflammation (hsCRP, ICAM-1 and VCAM-1), as it is apparent from previous studies that hyperhomocysteinemia stimulates the synthesis of CRP and the expression of adhesion molecules.

• Authors: Aleksandra Baszczuk, Zygmunt Kopczyński, Jarosław Kopczyński, Maciej Cymerys, Anna Thielemann, Lena Bielawska, Anna Banaszewska
• Journal: Postepy higieny i medycyny doswiadczalnej (Online) (Postepy Hig Med Dosw (Online)) Vol. 69 Pg. 429-35 (Apr 07 2015) ISSN: 1732-2693 [Electronic] Poland
• PMID: 25897102 (Publication Type: Journal Article)

Chemical References

• Folic Acid

Topics

• Adult
• Aged
• Arterial Pressure (drug effects)
• Female
• Folic Acid (therapeutic use)
• Humans
• Hypertension (complications)
• Inflammation (drug therapy, etiology)
• Male
• Middle Aged
• Young Adult