Abstract | OBJECTIVES: METHODS: The changes in BMP-2, -4, and -7 gene expressions in PBMCs were measured after stimulation by tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). The correlation of increase in gene expression with clinical and radiographic findings in patients with AS were analyzed. RESULTS: Both TNF-α and IL-1β could enhance BMP-2 expression in PBMCs from AS patients. Increases in BMP-2, -4, and -7 expressions in PBMCs positively correlated with total modified Stoke Ankylosing Spondylitis Spinal Score (all p < 0.05). Moreover, increases in BMP-2, -4, and -7 gene expressions after TNF-α and IL-1β stimulation were greater among AS patients with versus without severe sacroiliitis (all p < 0.05). Increases in BMP-2 and -7 expressions were greater in PBMCs from 4 patients with total (cervical, thoracic, and lumbar) spinal ankylosis than in the 8 patients who did not have total spinal ankylosis (all p < 0.05). CONCLUSIONS: In AS, inflammation upregulates the expression of BMPs in PBMCs which may lead to the radiographic progression with new bone formation.
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Authors | Ming-Han Chen, Hung-An Chen, Wei-Sheng Chen, Ming-Huang Chen, Chang-Youh Tsai, Chung-Tei Chou |
Journal | Modern rheumatology
(Mod Rheumatol)
Vol. 25
Issue 6
Pg. 913-8
( 2015)
ISSN: 1439-7609 [Electronic] England |
PMID | 25835314
(Publication Type: Journal Article)
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Chemical References |
- BMP2 protein, human
- BMP4 protein, human
- BMP7 protein, human
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Protein 7
- Interleukin-1beta
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bone Morphogenetic Protein 2
(genetics, metabolism)
- Bone Morphogenetic Protein 4
(genetics, metabolism)
- Bone Morphogenetic Protein 7
(genetics, metabolism)
- Disease Progression
- Female
- Gene Expression
(drug effects)
- Humans
- Interleukin-1beta
(pharmacology)
- Leukocytes, Mononuclear
(drug effects, metabolism)
- Male
- Middle Aged
- Radiography
- Spondylitis, Ankylosing
(diagnostic imaging, genetics, metabolism)
- Tumor Necrosis Factor-alpha
(pharmacology)
- Up-Regulation
- Young Adult
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