Bone Morphogenetic Proteins (Bone Morphogenetic Protein)

Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Also Known As:

Networked: 1832 relevant articles (20 outcomes, 173 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Morrell, Nicholas W: 47 articles (01/2022 - 04/2002)
2.	Kaplan, Frederick S: 30 articles (01/2022 - 04/2003)
3.	Shore, Eileen M: 28 articles (01/2022 - 04/2003)
4.	Jiang, Wen G: 20 articles (01/2020 - 02/2007)
5.	Ye, Lin: 20 articles (01/2020 - 02/2007)
6.	Upton, Paul D: 19 articles (07/2020 - 04/2002)
7.	Ten Dijke, Peter: 17 articles (10/2022 - 08/2002)
8.	Miyazono, Kohei: 17 articles (01/2022 - 09/2002)
9.	Yu, Paul B: 17 articles (01/2021 - 12/2004)
10.	Long, Lu: 16 articles (07/2020 - 05/2005)

Related Diseases

1.	Wounds and Injuries (Trauma) 09/01/2013 - "Since bone morphogenetic proteins (BMPs) are indicative of bone reconstitution, this study aimed to evaluate histological and immunohistochemically the temporal location of BMP-2 and BMP-4 in osteoblasts of rat alveolar wounds filled with demineralized human dentine matrix (DHDM), used as a graft material. " 12/01/2009 - "Health care system costs (direct health care costs) and costs for productivity losses (indirect health care costs) were calculated using the raw data from the Bone Morphogenetic Protein Evaluation Group in Surgery for Tibial Trauma "BESTT study". " 01/01/2019 - "Using a bone morphogenetic protein-responsive reporter mouse model, we showed that activation of the bone morphogenetic protein signalling pathway involves primarily astrocytes that demarcate the wound area. " 01/01/2019 - "To investigate the role of Gremlin-1, which is an endogenous antagonist of the bone morphogenetic protein (BMP) signaling pathway, in inducing epithelium-mesenchymal transition (EMT) in fetal RPE cells after repeated wounds. " 07/01/2017 - "Bone Morphogenetic Protein: Is There Still a Role in Orthopedic Trauma in 2017?"
2.	Pseudarthrosis (Pseudoarthrosis) 11/17/2021 - "Pseudarthrosis was resected, and the defect was bridged with an iliac crest autograft, supplemented with bone morphogenetic protein, and fixed with an elastic stable intramedullary nail. " 03/01/2017 - "The use of bone morphogenetic proteins (BMP) and pseudarthrosis, a literature review." 08/01/2012 - "Masquelet's procedure and bone morphogenetic protein in congenital pseudarthrosis of the tibia in children: a case series and meta-analysis." 04/01/1996 - "Partially purified canine bone morphogenetic protein (cBMP) was used in the repair of a delayed union fracture and a pseudoarthrosis. " 04/01/2016 - "We performed a systematic review of the literature to determine the safety and efficacy of bone morphogenetic protein (BMP) compared with bone graft when used specifically for revision spinal fusion surgery secondary to pseudarthrosis. "
3.	Osteosarcoma (Osteogenic Sarcoma) 02/22/2023 - "This study aimed to get a deeper insight into new osteosarcoma (OS) signature based on bone morphogenetic proteins (BMPs)-related genes and to confirm the prognostic pattern to speculate on the overall survival among OS patients. " 06/01/1998 - "The objective of this study was two-fold: to clarify the origins of bone-forming cells in human osteosarcoma transplanted into nude mice; and to examine the role of bone morphogenetic proteins (BMPs) in the tumour-induced osteogenesis. " 01/01/1996 - "In this study the chemotactic effects of the bone morphogenetic proteins BMP-2, -4, and -6 have been quantitated toward human osteoblasts, human marrow stromal osteoblasts, and U2-OS human osteosarcoma cells. " 12/01/2021 - "Effect of miRNA-200a on radiosensitivity of osteosarcoma cells by targeting Bone morphogenetic protein receptor 2." 11/01/2014 - "Roles of bone morphogenetic protein signaling in osteosarcoma."
4.	Postmenopausal Osteoporosis 11/01/2019 - "The present study aimed to investigate bone morphogenetic protein (BMP)-2 and microRNA (miR)-410 expression and the mechanism of regulation in serum and CD14+ peripheral blood mononuclear cells (PBMCs) from postmenopausal osteoporosis patients and model mice. " 01/07/2022 - "Estrogen, an important medicinal component for the preventative and therapeutic treatment of postmenopausal osteoporosis, induces osteogenesis by activating the estrogen receptor signaling pathway and upregulating the expression of osteogenic genes, such as bone morphogenetic proteins (BMPs). " 01/01/2017 - "The experimental studies indicated their potential use as treatment for postmenopausal osteoporosis and investigated the underlying mechanisms including osteoprotegerin/receptor activator of nuclear factor κB ligand (OPG/RANKL), extracellular-signal-regulated kinase/c-Jun N terminal kinase/mitogen-activated protein kinase (ERK/JNK/MAPK), estrogen receptor (ER), bone morphogenetic protein (BMP), transforming growth factor (TGF)-β, Wnt/β-catenin, and Notch signaling pathways. "
5.	Pulmonary Hypertension 01/01/2017 - "This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new treatment option against PH. What advances does it highlight? " 12/01/2022 - "Germline mutation in bone morphogenetic protein type II (BMPR2) is the most common cause of idiopathic/heritable pulmonary hypertension in pediatric patients. " 01/01/2017 - "The bone morphogenetic protein (BMP)-mediated signalling pathway plays crucial roles in the development and progression of pulmonary hypertension (PH). " 01/01/2017 - "Bone morphogenetic protein signalling in pulmonary hypertension: advances and therapeutic implications." 12/01/2014 - "Dysregulation of the bone morphogenetic protein receptor type 2 (BMPR2) is a hallmark feature that has been described in several forms of pulmonary hypertension. "

Related Drugs and Biologics

1.	Bone Morphogenetic Protein 7
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Cytokines
4.	Estrogen Receptors
5.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole
6.	Fibroblast Growth Factors (Fibroblast Growth Factor)
7.	Platelet-Derived Growth Factor
8.	Estrogens (Estrogen)
9.	Nestin
10.	Brain-Derived Neurotrophic Factor (BDNF)

Related Therapies and Procedures

1.	Spinal Fusion (Spondylosyndesis)
2.	Intramedullary Fracture Fixation
3.	Drug Therapy (Chemotherapy)
4.	Transplantation
5.	Low-Level Light Therapy (LLLT)