Bone Morphogenetic Proteins (Bone Morphogenetic Protein)

Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

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Networked: 926 relevant articles (10 outcomes, 70 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kaplan, Frederick S: 21 articles (12/2012 - 04/2003)
2.	Shore, Eileen M: 21 articles (12/2012 - 04/2003)
3.	Jiang, Wen G: 16 articles (05/2013 - 02/2007)
4.	Ye, Lin: 14 articles (05/2013 - 02/2007)
5.	Morrell, Nicholas W: 10 articles (11/2013 - 05/2007)
6.	Yu, Paul B: 7 articles (11/2015 - 03/2009)
7.	Miyazono, Kohei: 7 articles (11/2013 - 03/2003)
8.	Oh, Sang Cheul: 6 articles (12/2015 - 09/2008)
9.	Ten Dijke, Peter: 6 articles (11/2015 - 08/2002)
10.	Wang, Jeffrey C: 6 articles (10/2015 - 05/2008)

Related Diseases

1.	Wounds and Injuries (Trauma) 12/01/2009 - "Health care system costs (direct health care costs) and costs for productivity losses (indirect health care costs) were calculated using the raw data from the Bone Morphogenetic Protein Evaluation Group in Surgery for Tibial Trauma "BESTT study". " 10/01/2015 - "Bone morphogenetic protein signaling promotes morphogenesis of blood vessels, wound epidermis, and actinotrichia during fin regeneration in zebrafish." 09/01/2015 - "Genes associated with bone morphogenetic protein signaling, such as bmp2, nog, and dlx5, were activated in the extraction wounds of the ALN-treated animals. " 04/15/2015 - "Mutant mice developed ectopic cartilage and bone at the distal joints of the extremities including the interphalangeal joints and hind limb ankles as early as P4 in the absence of trauma or exogenous bone morphogenetic protein (BMP) administration. " 03/01/2014 - "Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration."
2.	Osteosarcoma (Osteogenic Sarcoma) 06/01/1998 - "The objective of this study was two-fold: to clarify the origins of bone-forming cells in human osteosarcoma transplanted into nude mice; and to examine the role of bone morphogenetic proteins (BMPs) in the tumour-induced osteogenesis. " 01/01/1996 - "In this study the chemotactic effects of the bone morphogenetic proteins BMP-2, -4, and -6 have been quantitated toward human osteoblasts, human marrow stromal osteoblasts, and U2-OS human osteosarcoma cells. " 11/01/2014 - "Roles of bone morphogenetic protein signaling in osteosarcoma." 03/01/2013 - "It was recently suggested that bone morphogenetic protein (BMP)-2 may be useful for treating osteosarcoma cells. " 03/01/2013 - "Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9."
3.	Tibial Fractures (Fracture, Tibial) 11/01/2012 - "To systematically assess the clinical efficacy of bone morphogenetic proteins in the treatment of open tibial fractures. " 01/01/2015 - "Bone Morphogenetic Protein for the Healing of Tibial Fracture: A Meta-Analysis of Randomized Controlled Trials." 11/01/2012 - "Randomized controlled trials (RCTs) of bone morphogenetic protein for the treatment of open tibial fractures were included. " 02/01/2008 - "More recent prospectively acquired data about open tibial fractures, gathered from a randomized trial of the effects of bone morphogenetic protein (BMP), showed that one year after injury, more than half of the patients who were managed with the current standard of care had treatment failure. " 11/01/2012 - "Bone morphogenetic protein has certain advantages in treating open tibial fractures. "
4.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2010 - "The purpose of this study was to evaluate the extent of bone morphogenetic protein (BMP)-specific intrathecal signaling after application to the spine at various time points after a spinal cord injury (SCI). " 06/01/2011 - "To observe the expression pattern of bone morphogenetic protein receptor IA (BMPR IA) in rats after contusive spinal cord injury. " 06/01/2011 - "[Expression of bone morphogenetic protein receptor IA in rats after contusive spinal cord injury]." 02/01/2010 - "Bone morphogenetic proteins mediate cellular response and, together with Noggin, regulate astrocyte differentiation after spinal cord injury." 01/01/2008 - "They also confirm the particular promise of GDAs treated with bone morphogenetic protein for spinal cord injury repair."
5.	Glioblastoma (Glioblastoma Multiforme) 12/07/2006 - "Here we report that bone morphogenetic proteins (BMPs), amongst which BMP4 elicits the strongest effect, trigger a significant reduction in the stem-like, tumour-initiating precursors of human glioblastomas (GBMs). " 01/01/2012 - "In our previous study, we detected decreased expression of phospho-Smad1/5/8 and its upstream signaling molecule, bone morphogenetic protein receptor IB subunit (BMPR-IB), in certain glioblastoma tissues, unlike normal brain tissues. " 07/01/2010 - "In vivo, large numbers of bone morphogenetic protein-7-expressing neural precursors encircle brain tumours in young mice, induce canonical bone morphogenetic protein signalling in stem-like glioblastoma cells and can thereby attenuate tumour formation. " 01/01/2008 - "Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells." 01/01/2006 - "Bone morphogenetic proteins regulate tumorigenicity in human glioblastoma stem cells."

Related Drugs and Biologics

1.	Bone Morphogenetic Protein 7
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Fibroblast Growth Factors (Fibroblast Growth Factor)
4.	Platelet-Derived Growth Factor
5.	Transforming Growth Factor beta (TGF-beta)
6.	Transforming Growth Factors (Transforming Growth Factor)
7.	Retinaldehyde (Retinal)
8.	Bone Morphogenetic Protein Receptors
9.	Proteins (Proteins, Gene)
10.	Cytokines

Related Therapies and Procedures

1.	Intramedullary Fracture Fixation
2.	Transplantation (Transplant Recipients)
3.	Drug Therapy (Chemotherapy)
4.	Spinal Fusion (Spondylosyndesis)
5.	Transplants (Transplant)