Abstract | PURPOSE: PATIENTS AND METHODS: Patients enrolled onto this protocol were diagnosed with metastatic cervical cancer and had previously received platinum-based chemotherapy or chemoradiotherapy. Patients were treated with a single infusion of tumor-infiltrating T cells selected when possible for human papillomavirus (HPV) E6 and E7 reactivity (HPV-TILs). Cell infusion was preceded by lymphocyte-depleting chemotherapy and was followed by administration of aldesleukin. RESULTS: Three of nine patients experienced objective tumor responses (two complete responses and one partial response). The two complete responses were ongoing 22 and 15 months after treatment, respectively. One partial response was 3 months in duration. The HPV reactivity of T cells in the infusion product (as measured by interferon gamma production, enzyme-linked immunospot, and CD137 upregulation assays) correlated positively with clinical response (P = .0238 for all three assays). In addition, the frequency of HPV-reactive T cells in peripheral blood 1 month after treatment was positively associated with clinical response (P = .0238). CONCLUSION: Durable, complete regression of metastatic cervical cancer can occur after a single infusion of HPV-TILs. Exploratory studies suggest a correlation between HPV reactivity of the infusion product and clinical response. Continued investigation of this therapy is warranted.
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Authors | Sanja Stevanović, Lindsey M Draper, Michelle M Langhan, Tracy E Campbell, Mei Li Kwong, John R Wunderlich, Mark E Dudley, James C Yang, Richard M Sherry, Udai S Kammula, Nicholas P Restifo, Steven A Rosenberg, Christian S Hinrichs |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 33
Issue 14
Pg. 1543-50
(May 10 2015)
ISSN: 1527-7755 [Electronic] United States |
PMID | 25823737
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Copyright | Published by the American Society of Clinical Oncology. |
Topics |
- Adult
- Aged
- Alphapapillomavirus
- Female
- Humans
- Lymphatic Metastasis
- Middle Aged
- Remission Induction
- T-Lymphocytes, Cytotoxic
- Uterine Cervical Neoplasms
(pathology, therapy)
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