Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.

Abstract

BACKGROUND:

Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin complement pathway. CL-K1 is preferentially expressed in the kidneys, but also in other organs and it is considered to play a role in host defense to some infectious agents. Schistosome teguments are fucosylated and CL-K1 has, through its collagen-like domain, a high binding affinity to fucose.

METHODOLOGY/PRINCIPAL FINDINGS:

We utilized a Nigerian study group consisting of 167 Schistosoma haematobium infected individuals and 186 matched healthy subjects, and investigated the contribution of CL-K1 deficiency and of COLEC11 polymorphisms to infection phenotype. Higher CL-K1 serum levels were associated with decreased risk of schistosome infection (P corr = 0.0004). CL-K1 serum levels were differentially distributed between the COLEC11 genotypes and haplotypes observed. The non-synonymous variant p.R216H was associated with the occurrence of schistosomiasis (OR = 0.44, 95%CI = 0.22-0.72, P corr = 0.0004). The reconstructed COLEC11*TCCA haplotypes were associated with higher CL-K1 serum levels (P = 0.002) and with decreased schistosomiasis (OR = 0.38, 95%CI = 0.23-0.63, P corr = 0.0001).

CONCLUSIONS:

In agreement with findings from our earlier published study, our findings support the observation that CL-K1 and their functional variants may be host factors associated with protection in schistosomiasis and may be a useful marker for further investigations.

• Authors: Justin S Antony, Olusola Ojurongbe, Peter G Kremsner, Thirumalaisamy P Velavan
• Journal: PLoS neglected tropical diseases (PLoS Negl Trop Dis) Vol. 9 Issue 3 Pg. e0003647 (Mar 2015) ISSN: 1935-2735 [Electronic] United States
• PMID: 25807310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Colec11 protein, human
• Collectins
• Receptors, Pattern Recognition
• Fucose

Topics

• Biomarkers (blood)
• Collectins (blood, deficiency, genetics, metabolism)
• Complement Pathway, Mannose-Binding Lectin (physiology)
• Disease Susceptibility (blood, metabolism)
• Fucose (metabolism)
• Haplotypes (genetics)
• Humans
• Neglected Diseases
• Nigeria
• Odds Ratio
• Receptors, Pattern Recognition (metabolism)
• Schistosomiasis haematobia (metabolism)