Abstract | BACKGROUND: METHODS: A total of 26 immature male piglets were subjected to 12-min VF followed by 8-min CPR. The treatment group (n=13) received i.v. (intravenous) boluses vasopressin 0.4 U/kg, esmolol 250 μg/kg and milrinone 25 μg/kg after 13 min, followed by i.v. boluses esmolol 375 μg/kg and milrinone 25 μg/kg after 18 min and continuous esmolol 15 μg/kg/h infusion during 180 min reperfusion, whereas controls (n=13) received equal amounts of vasopressin and saline. A 200 J monophasic counter- shock was delivered to achieve resumption of spontaneous circulation (ROSC) after 8 min CPR. If ROSC was not achieved, another 200 J defibrillation and bolus vasopressin 0.4 U/kg would be administered in both groups. Direct current shocks at 360 J were applied as one shot per minute over maximally 5 min. Hemodynamic variables and troponin I as a marker of cardiac injury were recorded. RESULTS:
Troponin I levels after 180 min reperfusion were lower in the treatment group than in controls (P<0.05). The treatment group received less norepinephrine (P<0.01) and had greater diuresis (P<0.01). There was no difference in survival between groups. CONCLUSION:
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Authors | F Zoerner, F Lennmyr, L Wiklund, C Martijn, E Semenas |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 59
Issue 4
Pg. 465-74
(Apr 2015)
ISSN: 1399-6576 [Electronic] England |
PMID | 25790148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. |
Chemical References |
- Adrenergic beta-Antagonists
- Cardiotonic Agents
- Propanolamines
- Troponin I
- Vasoconstrictor Agents
- Vasopressins
- Milrinone
- esmolol
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Topics |
- Acid-Base Equilibrium
- Adrenergic beta-Antagonists
(therapeutic use)
- Animals
- Cardiopulmonary Resuscitation
- Cardiotonic Agents
(therapeutic use)
- Fluid Therapy
- Heart Arrest
(complications, pathology)
- Heart Diseases
(pathology, prevention & control)
- Male
- Milrinone
(therapeutic use)
- Myocardium
(pathology)
- Propanolamines
(therapeutic use)
- Survival Analysis
- Swine
- Troponin I
(blood)
- Vasoconstrictor Agents
(therapeutic use)
- Vasopressins
(therapeutic use)
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