Obesity is caused by an imbalance between caloric intake and energy expenditure and accumulation of excess
lipids in adipose tissues. Recent studies have demonstrated that
green tea and its processed products (e.g., oolong and
black tea) are introduced to exert beneficial effects on lipid metabolism. Here, we propose that fermented
green tea (FGT) extract, as a novel processed
green tea, exhibits antiobesity effects. FGT reduced
body weight gain and fat mass without modifying food intake.
mRNA expression levels of lipogenic and inflammatory genes were downregulated in white adipose tissue of FGT-administered mice. FGT treatment alleviated
glucose intolerance and
fatty liver symptoms, common complications of
obesity. Notably, FGT restored the changes in gut microbiota composition (e.g., the Firmicutes/Bacteroidetes and Bacteroides/Prevotella ratios), which is reported to be closely related with the development of
obesity and
insulin resistance, induced by high-fat diets. Collectively, FGT improves
obesity and its associated symptoms and modulates composition of gut microbiota; thus, it could be used as a novel dietary component to control
obesity and related symptoms.