Abstract | INTRODUCTION: CASE SUMMARY: A 61-year-old woman with poorly controlled type 2 diabetes who presented with bilateral foot pain was found to have bilateral calcaneal osteomyelitis. She was started on an antibiotic regimen that included daptomycin. Within 1 week, she developed fever, a dry cough, and shortness of breath and was treated for hospital-acquired pneumonia (HAP). Daptomycin was discontinued. Upon completion of therapy for HAP, the patient was subsequently restarted on daptomycin for continued therapy of bilateral calcaneal osteomyelitis. Within 48 hours of restarting daptomycin, the patient developed hypoxemic respiratory failure, bilateral pulmonary infiltrates, and peripheral eosinophilia. Bronchoscopic lavage revealed 30% eosinophils. Daptomycin-induced acute eosinophilic pneumonia was diagnosed. Daptomycin was discontinued, and the patient had complete resolution of symptoms, peripheral eosinophilia, and radiographic findings. DISCUSSION:
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Authors | Jayshil J Patel, Agith Antony, Maria Herrera, Randolph J Lipchik |
Journal | WMJ : official publication of the State Medical Society of Wisconsin
(WMJ)
Vol. 113
Issue 5
Pg. 199-201
(Oct 2014)
ISSN: 1098-1861 [Print] United States |
PMID | 25739164
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Daptomycin
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Topics |
- Acute Disease
- Anti-Bacterial Agents
(adverse effects)
- Daptomycin
(adverse effects)
- Diagnosis, Differential
- Female
- Humans
- Middle Aged
- Osteomyelitis
(drug therapy)
- Pulmonary Eosinophilia
(chemically induced)
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