Abstract | PURPOSE: EXPERIMENTAL:
Tumor tissue samples were collected from our patient cohort consisting of 335 NSCLC patients with stage I-IIIA disease. Tissue microarrays (TMAs) were constructed, and immunohistochemical (IHC) analyses were performed to evaluate the PR expression in the tumor epithelial and stromal compartments. RESULTS: In a univariate analysis, positive PR expression in the stromal tumor compartment (P=0.005) was significantly and independently associated with a favorable outcome for both genders. Furthermore, positive PR expression in tumor epithelial cells (P=0.003) correlated with a poor prognosis for female patients. In a multivariate analysis, positive PR expression in the tumor stroma (P=0.007) was an independent prognostic factor for improved disease-specific survival (DSS). Positive PR expression in tumor epithelial cells emerged as an independent prognostic factor in female patients (P=0.001) for poor DSS. CONCLUSIONS: We show that PR expression in tumor-surrounding stromal cells is associated with improved DSS for both male and female patients. Additionally, we reveal that positive PR expression in tumor epithelial cells is an independent, unfavorable prognosticator for DSS in female patients, making PR expression a potential marker for prognostic stratification in NSCLC.
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Authors | Kaja Skjefstad, Elin Richardsen, Tom Donnem, Sigve Andersen, Yury Kiselev, Thea Grindstad, Sigurd M Hald, Khalid Al-Shibli, Roy M Bremnes, Lill-Tove Busund, Samer Al-Saad |
Journal | Steroids
(Steroids)
Vol. 98
Pg. 29-36
(Jun 2015)
ISSN: 1878-5867 [Electronic] United States |
PMID | 25668612
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Neoplasm Proteins
- Receptors, Progesterone
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Topics |
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
(metabolism, mortality, pathology)
- Disease-Free Survival
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms
(metabolism, mortality, pathology)
- Male
- Middle Aged
- Neoplasm Proteins
(biosynthesis)
- Neoplasm Staging
- Receptors, Progesterone
(biosynthesis)
- Retrospective Studies
- Sex Characteristics
- Stromal Cells
(metabolism, pathology)
- Survival Rate
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