Abstract | PURPOSE: This study aims at using 18F-FDG microPET to monitor the brown adipose tissue (BAT) glucose metabolism in obese and diabetic mouse models under different interventions, and study the therapeutic potential of BAT activation for weight loss and lowering of blood glucose in these models. METHODS: RESULTS: Compared with the controls, the obese mice and DM mice showed successively lower 18F-FDG uptake in the interscapular BAT (P = 0.036 and < 0.001, respectively). After two-week BRL37344 treatment, the BAT uptake was significantly elevated in both obese mice (P = 0.010) and DM mice (P = 0.004), accompanied with significantly decreased blood glucose levels (P = 0.023 and 0.036, respectively). The BAT uptake was negatively correlated with the blood glucose levels in both obese mice (r = -0.71, P = 0.003) and DM mice (r = -0.74, P = 0.010). BRL37344 treatment also caused significant weight loss in the obese mice (P = 0.001). Levothyroxine treatment increased the BAT uptake in the control mice (P = 0.025) and obese mice (P = 0.013), but not in the DM mice (P = 0.45). CONCLUSION: The inhibited BAT function in obese and DM mice can be re-activated by β3-adrenergic receptor agonist or thyroid hormone, and effective BAT activation may lead to weight loss and blood glucose lowering. Activating BAT can provide a new treatment strategy for obesity and DM.
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Authors | Chenxi Wu, Wuying Cheng, Yi Sun, Yonghong Dang, Fengying Gong, Huijuan Zhu, Naishi Li, Fang Li, Zhaohui Zhu |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 12
Pg. e113742
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25462854
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Insulin
- Fluorodeoxyglucose F18
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Topics |
- Adipose Tissue, Brown
(drug effects, metabolism)
- Animals
- Blood Glucose
- Diabetes Mellitus
(metabolism, pathology, therapy)
- Diabetes Mellitus, Experimental
(metabolism, pathology, therapy)
- Diet, High-Fat
- Fluorodeoxyglucose F18
(administration & dosage, metabolism)
- Humans
- Insulin
(metabolism)
- Mice
- Mice, Inbred NOD
- Mice, Obese
- Obesity
(metabolism, pathology, therapy)
- Positron-Emission Tomography
- Weight Loss
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