Intercellular adhesion molecule 1 and progression of percent emphysema: the MESA Lung Study.

Abstract

BACKGROUND:

Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline.

METHODS:

The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease in 2000-02. The MESA Lung Study assessed percent emphysema (<-950 Hounsfield units) on cardiac (2000-07) and full-lung CT scans (2010-12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors.

RESULTS:

Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function.

CONCLUSIONS:

Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.

• Authors: Carrie P Aaron, Joseph E Schwartz, Suzette J Bielinski, Eric A Hoffman, John H M Austin, Elizabeth C Oelsner, Kathleen M Donohue, Ravi Kalhan, Cecilia Berardi, Joel D Kaufman, David R Jacobs Jr, Russell P Tracy, R Graham Barr
• Journal: Respiratory medicine (Respir Med) Vol. 109 Issue 2 Pg. 255-64 (Feb 2015) ISSN: 1532-3064 [Electronic] England
• PMID: 25457724 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• E-Selectin
• Intercellular Adhesion Molecule-1

Topics

• Aged
• E-Selectin (blood)
• Female
• Forced Expiratory Volume (physiology)
• Humans
• Intercellular Adhesion Molecule-1 (blood)
• Male
• Middle Aged
• Pulmonary Emphysema (diagnostic imaging)
• Spirometry
• Tomography, X-Ray Computed (methods)
• Vital Capacity (physiology)