Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.

Abstract

A strain of Streptoverticillium cinnamoneum produced a peptide antibiotic named lanthiopeptin, which contained four unusual amino acids, erythro-beta-hydroxyaspartic acid, mesolanthionine, threo-beta-methyllanthionine and lysinoalanine. Lanthiopeptin showed antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells by cytopathic effect reduction assay. The structure of lanthiopeptin is similar to that of ancovenin.

• Authors: N Naruse, O Tenmyo, K Tomita, M Konishi, T Miyaki, H Kawaguchi, K Fukase, T Wakamiya, T Shiba
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 42 Issue 6 Pg. 837-45 (Jun 1989) ISSN: 0021-8820 [Print] England
• PMID: 2544544 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Anti-Bacterial Agents
• Antifungal Agents
• Antiviral Agents
• Peptides
• Peptides, Cyclic
• lanthiopeptin

Topics

• Amino Acid Sequence
• Amino Acids (analysis)
• Animals
• Anti-Bacterial Agents (analysis, biosynthesis, isolation & purification, pharmacology)
• Antifungal Agents (analysis, biosynthesis, isolation & purification, pharmacology)
• Antiviral Agents (analysis, biosynthesis, isolation & purification, pharmacology)
• Bacteria (drug effects)
• Chromatography, Gel
• Cytopathogenic Effect, Viral (drug effects)
• Fermentation
• Magnetic Resonance Spectroscopy
• Molecular Sequence Data
• Peptide Biosynthesis
• Peptides (analysis, isolation & purification, pharmacology)
• Peptides, Cyclic
• Simplexvirus (drug effects)
• Soil Microbiology
• Solubility
• Spores, Bacterial
• Streptomycetaceae (growth & development, metabolism, physiology)
• Vero Cells