[Modeling of schizophrenia with Levodopa + Carbidopa].

Abstract

Animal experimental modeling of mental disorders helps revealing mechanisms of the diseases and identifying effective methods of their treatment. The aim this study was to develop a new model of schizophrenia by oral Levodopa + Carbidopa (LC) administration. It was found that introduction of LC to rats induced a significant reduction of emotional reactions, hypersensitivity to a sound, a decreased exploratory activity and stereotype behavior, locomotor hyperactivity in some rats. It is concluded that LC introduction to rats may be used as an alternative dopaminergic animal model of schizophrenia.

• Authors: E O Kucher, A Iu Egorov, N A Chernikova, E V Filatova
• Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii (Zh Evol Biokhim Fiziol) 2013 Sep-Oct Vol. 49 Issue 5 Pg. 352-6 ISSN: 0044-4529 [Print] Russia (Federation)
• PMID: 25434191 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dopamine Agonists
• Drug Combinations
• carbidopa, levodopa drug combination
• Levodopa
• Carbidopa

Topics

• Animals
• Behavior, Animal (drug effects)
• Carbidopa (adverse effects, pharmacology)
• Disease Models, Animal
• Dopamine Agonists (adverse effects, pharmacology)
• Drug Combinations
• Levodopa (adverse effects, pharmacology)
• Male
• Rats
• Rats, Wistar
• Schizophrenia (chemically induced, physiopathology)