Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia.
|
| Abstract |
Obesity is associated with poorer event-free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL). Persistent minimal residual disease (MRD) in the bone marrow as measured by multidimensional flow cytometry (MDF) is a key early prognostic indicator and is strongly associated with EFS. We therefore hypothesized that obesity during induction would be associated with positive end-of-induction MRD (≥0.01%). We analyzed MDF of end-induction bone marrow samples from a historical cohort of 198 children newly diagnosed with B-precursor ALL (BP-ALL) and treated with Children's Oncology Group induction regimens. We assessed the influence of body mass index on risk for positive end-induction MRD in the bone marrow. In our cohort of BP-ALL, 30 children (15.2%) were overweight and 41 (20.7%) were obese at diagnosis. Independent of established predictors of treatment response, obesity during induction was associated with significantly greater risk for persistent MRD (odds ratio, 2.57; 95% confidence interval, 1.19 to 5.54; P = .016). Obesity and overweight were associated with poorer EFS irrespective of end-induction MRD (P = .012). Obese children with newly diagnosed BP-ALL are at increased risk for positive end-induction MRD and poorer EFS.
|
|---|---|
| Authors | Etan Orgel, Jonathan Tucci, Waseem Alhushki, Jemily Malvar, Richard Sposto, Cecilia H Fu, David R Freyer, Hisham Abdel-Azim, Steven D Mittelman |
| Journal | Blood (Blood) Vol. 124 Issue 26 Pg. 3932-8 (Dec 18 2014) ISSN: 1528-0020 [Electronic] United States |
| PMID | 25349177 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2014 by The American Society of Hematology. |
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!