Abstract | OBJECTIVE: To assess the iodine nutritional status and investigate the prevalence of thyroid diseases in a community population in Chengdu, China. METHODS: Eighty school-age children were randomly selected for measurements of urinary iodine concentration. A total of 1500 residents over the age of 18 who had lived in Chengdu for more than 5 years were selected by stratified cluster sampling. Serum thyroid hormone concentrations and thyroid autoantibodies were measured, and thyroid ultrasonography was performed. RESULTS: The median urine iodine concentration was 184 µg/l in school-age children. The prevalence of clinical hyperthyroidism, subclinical hyperthyroidism, clinical hypothyroidism and subclinical hypothyroidism was 0.97%, 1.95%, 0.90% and 5.55%, respectively. The prevalence of thyroid autoantibodies and thyroid nodules was 15.82% and 16.87%, respectively. The prevalence of clinical hyper- and hypothyroidism was greater in females than in males (P < 0.05). The prevalence of subclinical hyper- and hypothyroidism, thyroid nodules and thyroid autoantibodies increased significantly with age (P < 0.05). The rate of new abnormal TSH was 9.37%, and the average serum Thyroid Stimulating Hormone (TSH) concentrations increased with age. When TSH >0.71 mU/l, the prevalence of positive TPOAb and/or TgAb increased significantly with rising concentrations of TSH (P < 0.05); however, the prevalence of thyroid nodules did not increase with escalating concentrations of TSH (P = 0.09). CONCLUSION:
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Authors | Y R Yan, Y Liu, H Huang, Q G Lv, X L Gao, J Jiang, N W Tong |
Journal | QJM : monthly journal of the Association of Physicians
(QJM)
Vol. 108
Issue 5
Pg. 379-85
(May 2015)
ISSN: 1460-2393 [Electronic] England |
PMID | 25336254
(Publication Type: Journal Article)
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Copyright | © The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: [email protected]. |
Chemical References |
- Autoantibodies
- Thyroid Hormones
- Thyrotropin
- Iodine
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Topics |
- Adolescent
- Adult
- Age Distribution
- Aged
- Aged, 80 and over
- Autoantibodies
(blood)
- Child
- China
(epidemiology)
- Epidemiologic Studies
- Female
- Humans
- Iodine
(urine)
- Male
- Middle Aged
- Nutritional Status
- Sex Distribution
- Thyroid Diseases
(epidemiology)
- Thyroid Gland
(diagnostic imaging)
- Thyroid Hormones
(blood)
- Thyroid Nodule
(epidemiology)
- Thyrotropin
(blood)
- Ultrasonography
- Young Adult
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