SFTS virus infection in nonhuman primates.
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| Abstract |
SFTS virus (SFTSV) is a highly pathogenic bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease in China. Laboratory mice have been reported to be susceptible to SFTSV infection, but the infection in nonhuman primates has not been investigated. This study is the first to report that, in rhesus macaques, SFTSV does not cause severe symptoms or death but causes fever, thrombocytopenia, leukocytopenia, and increased levels of transaminases and myocardial enzymes in blood. Viremia, virus-specific immunoglobulin M and immunoglobulin G antibodies, and neutralizing antibodies were identified in all infected macaques. Levels of the cytokines interferon γ, eotaxin, tumor necrosis factor α, and macrophage inflammatory protein 1β were significantly elevated in the blood. Minor pathological lesions were observed in the liver and kidney during the late stages of infection. Overall, SFTSV infection in rhesus macaques resembled mild SFTS in humans.
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| Authors | Cong Jin, Hong Jiang, Mifang Liang, Ying Han, Wen Gu, Fushun Zhang, Hua Zhu, Wei Wu, Ting Chen, Chuan Li, Weilun Zhang, Quanfu Zhang, Jing Qu, Qiang Wei, Chuan Qin, Dexin Li |
| Journal | The Journal of infectious diseases (J Infect Dis) Vol. 211 Issue 6 Pg. 915-25 (Mar 15 2015) ISSN: 1537-6613 [Electronic] United States |
| PMID | 25326554 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected]. |
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