The aim of the present study was to evaluate the in vitro anti-
cancer and
anti-oxidant potential of
methanol extract of Blumea eriantha as well as its
phytochemical characterization. The in vitro cytotoxic and antiproliferative activities of B. eriantha methanolic extract of leaves were evaluated using MTT assay on HeLa and B16F10 cell lines, and
wound scratch and colony formation assays on B16F10 cell lines. The expressions of p53 and Bcl-2 genes were also determined by
reverse transcriptase-polymerase chain reaction to establish apoptosis. Isolation and identification of chemical constituents were carried out by various chromatographic and spectroscopic analytical techniques including HPTLC and LC-MS. The
methanol extract of the leaves of B. eriantha showed potent in vitro
antioxidant and anticancer properties. Moreover, the extract showed significant loss of wound healing, thus suggesting that it could prevent a possible
metastasis. Hence, B. eriantha could be explored as a potential anticancer plant with antimetastatic properties.