Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity.
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| Abstract |
The G-protein-coupled receptor 120 (GPR120) is a receptor for polyunsaturated fatty acids with anti-inflammatory activity. The R270H variant of GPR120 enhances inflammation in adipose and hepatic tissues. We investigated whether the R270H variant could play a role in determining liver injury in children and adolescents with obesity. Five hundred eighty-one children with obesity were studied. No homozygotes and 20 heterozygotes for the 270H allele were found. Heterozygotes showed higher alanine transaminase (ALT) levels (P = 0.01) than wild-type subjects, and also showed an odds ratio to have pathologic ALT of 3.2 (95% confidence interval [CI] 1.2-8.0, P < 0.05). Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis. Stratifying the patients with the GPR120 270H variant on the basis of their PNPLA3 polymorphism, we demonstrated a significant interaction effect on ALT levels (P = 0.00001), suggesting a driving effect of the PNPLA3 148M allele on liver injury in children with obesity carrying this variant.
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| Authors | Pierluigi Marzuillo, Anna Grandone, Mariasole Conte, Francesco Capuano, Grazia Cirillo, Anna Di Sessa, Giuseppina R Umano, Roberta Romano, Laura Perrone, Emanuele Miraglia del Giudice |
| Journal | Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 59 Issue 4 Pg. 472-5 (Oct 2014) ISSN: 1536-4801 [Electronic] United States |
| PMID | 25250621 (Publication Type: Journal Article) |
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