Phospholipases (Phospholipase)

05/01/1999 - "Mutational analysis of phospholipase A2A: a positional candidate susceptibility gene for bipolar disorder."
11/01/1998 - "Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder."
09/01/2008 - "Thus, AA turnover and brain expression of AA-selective cytosolic phospholipase A(2) (cPLA(2)), but not DHA turnover or expression of DHA-selective Ca(2+)-independent iPLA(2), are reduced in rats given agents effective against bipolar disorder mania, whereas experimental excitotoxicity and neuroinflammation selectively increase brain AA metabolism. "
04/08/2001 - "Recently, we have found an association between bipolar disorder patients who are excellent responders to lithium prophylaxis and a polymorphic marker located in the first intron of the phospholipase C-gamma1 gene (PLC-gamma1) [Turecki et al., 1998: Mol Psychiatry 3:534-538]. "
03/01/2001 - "The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism."

06/01/2001 - "Polyvalent antivenom produced by Instituto Clodomiro Picado was effective in the neutralization of: lethal; hemorrhagic; myotoxic; coagulant; defibrinating; and phospholipase A(2) activities, but ineffective against edema-forming activity. "
03/01/2012 - "The lethal, clotting, phospholipase, edema-inducing, hemorrhagic and myotoxic activities were partially inhibited by the different extracts and fractions. "
01/01/2011 - "γBjussuMIP mainly inhibited the pharmacological properties of Asp49 PLA2s, such as phospholipase, anticoagulant, myotoxic, edema inducing, cytotoxic, bactericidal and lethal activities. "
12/01/1999 - "Altogether, results suggest that this toxin is a new member of the Lys-49 phospholipase A2-homologues with myotoxic, cytolytic, and edema-inducing activities."
01/01/1994 - "3. The phospholipase A showed edema forming, indirect hemolytic and myonecrotic activities but not hemorrhagic activity."

07/01/2012 - "The objective of this study was to test the hypothesis that inhibition of the overexpressed secretory phospholipase A(2) and cytosolic phospholipase A(2) during sepsis benefits the disease's eventual outcome. "
07/01/2012 - "The results demonstrate that antisense strategy against secretory phospholipase A(2) IIa and cytosolic phospholipase A(2) IVa can inhibit their target protein expression in major organs and greatly improve the clinical outcome, i.e., an absolute reduction in 35-day mortality of 30.8%, in rats with sepsis. "
01/01/2010 - "The expression level of secretory group IIA phospholipase A(2) (sPLA(2)-IIA) is known to be elevated in inflammatory disorders including in sepsis. "
04/01/2008 - "Secretory phospholipase A(2) in newborn infants with sepsis."
01/01/2004 - "Protease and phospholipase inhibition protect Veneza zonata (Hemiptera Coreidae) against septicemia caused by parasite trypanosomatid 563DT."

01/01/2011 - "Secretory phospholipase A₂ pathway during pediatric acute respiratory distress syndrome: a preliminary study."
06/01/2012 - "Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome."
11/01/2010 - "Impaired phospholipases A₂production by stimulated macrophages from patients with acute respiratory distress syndrome."
12/21/2001 - "We investigated whether methylprednisolone, a synthetic glucocorticoid, could inhibit increase of phospholipase A(2) activity in the lung and lead to protection against a model of acute respiratory distress syndrome in rabbits. "
10/01/1992 - "Oxidants may play a central role in the pathogenesis of adult respiratory distress syndrome, and phospholipase activation is a potential mechanism of oxidant-induced injury of alveolar epithelial cells. "

11/01/2015 - "At 1 year, an allograft biopsy showed phospholipase A 2 receptor-negative membranous nephropathy. "
06/01/2012 - "This is a very early case of Phospholipase A(2) receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipase A(2) receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease."
01/01/2011 - "We discuss the relationship between membranous nephropathy and sarcoidosis based on the close appearance of the 2 diseases and the detection of phospholipase A₂ receptor in glomerular immune deposits."
01/01/2011 - "A case of phospholipase A₂ receptor-positive membranous nephropathy preceding sarcoid-associated granulomatous tubulointerstitial nephritis."
05/01/2015 - "Anti-phospholipase A₂ receptor antibodies in recurrent membranous nephropathy."