Autoantibodies to DNA mismatch repair enzymes in polymyositis/dermatomyositis and other autoimmune diseases: a possible marker of favorable prognosis.

Abstract	Objective. Myositis-specific autoantibodies(MSAs) are useful tools for identifying clinical subsets of patients with idiopathic inflammatory myopathies(IIMs). There have been few reports on antibodies to some DNA mismatch repair enzymes (MMREs) inpatients with IIMs. This study was undertaken to determine the frequencies and clinical associations of antibodies to 7 types of MMREs (MLH1, MLH3, MSH2,MSH3, MSH6, PMS1, and PMS2) in patients with IIMs and other systemic autoimmune diseases.Methods. Clinical data and serum samples were collected from 239 Japanese patients with IIMs (147 with adult dermatomyositis, 13 with juvenile dermatomyositis,57 with polymyositis, and 22 with myositis overlap syndrome). One hundred patients with other diseases, including 40 with systemic lupus erythematosus(SLE), were assessed as disease controls. The presence of anti-MMRE antibodies in serum was examined by immunoprecipitation, enzyme-linked immunosorbenassay, and immunoprecipitation/Western blotting.Results. Anti-MMRE antibodies were found in 1 patients with IIMs and 3 patients with SLE. They were restricted to MLH1, PMS1, MSH2, and PMS2, with simultaneous positivity for more than one of these antibodies occurring in some patients. Nine IIM patients with anti-MMREs also had other MSAs and their associated clinical features. All patients with anti-MMREs were still living at the time of the present analysis.Conclusion. Anti-MMRE antibodies, which often co exist with other MSAs, may be serologic markers forgood prognosis in IIMs.
Authors	Yoshinao Muro, Ran Nakashima, Yuji Hosono, Kazumitsu Sugiura, Tsuneyo Mimori, Masashi Akiyama
Journal	Arthritis & rheumatology (Hoboken, N.J.) (Arthritis Rheumatol) Vol. 66 Issue 12 Pg. 3457-62 (Dec 2014) ISSN: 2326-5205 [Electronic] United States
PMID	25186186 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adaptor Proteins, Signal Transducing Autoantibodies Carrier Proteins DNA-Binding Proteins G-T mismatch-binding protein MLH1 protein, human MLH3 protein, human MSH3 protein, human MutS Homolog 3 Protein Neoplasm Proteins Nuclear Proteins PMS1 protein, human Adenosine Triphosphatases PMS2 protein, human MSH2 protein, human Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutL Proteins MutS Homolog 2 Protein DNA Repair Enzymes
Topics	Adaptor Proteins, Signal Transducing (immunology) Adenosine Triphosphatases (immunology) Adolescent Adult Aged Arthritis, Rheumatoid (immunology) Autoantibodies (analysis) Carrier Proteins (immunology) Child, Preschool DNA Mismatch Repair DNA Repair Enzymes (immunology) DNA-Binding Proteins (immunology) Dermatomyositis (immunology) Female Humans Lupus Erythematosus, Systemic (immunology) Male Middle Aged Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutL Proteins MutS Homolog 2 Protein (immunology) MutS Homolog 3 Protein Neoplasm Proteins (immunology) Nuclear Proteins (immunology) Polymyositis (immunology) Sjogren's Syndrome (immunology) Young Adult

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