Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study.

Abstract

Camptocormia is defined as a marked dystonic flexion of the trunk in the sagittal plane. Camptocormia responds poorly to botulinum toxin injections, manipulation with dopaminergic treatment, and deep brain stimulation. We designed a prospective pilot study to assess the effect of apomorphine infusions on camptocormia. Five patients were enrolled. All five patients responded well to this treatment. The fact that camptocormia responds so well to apomorphine may be explained by the sustained stimulation of the ventrolateral striatal D1 receptors, alleviating this type of dystonia.

• Authors: Katerina Mensikova, Michaela Kaiserova, Miroslav Vastik, Sandra Kurcova, Petr Kanovsky
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 122 Issue 6 Pg. 835-9 (Jun 2015) ISSN: 1435-1463 [Electronic] Austria
• PMID: 25134820 (Publication Type: Journal Article)

Chemical References

• Dopamine Agonists
• Apomorphine

Topics

• Aged
• Apomorphine (administration & dosage)
• Dopamine Agonists (administration & dosage)
• Female
• Humans
• Injections, Subcutaneous
• Male
• Middle Aged
• Muscular Atrophy, Spinal (drug therapy, physiopathology)
• Parkinson Disease (drug therapy, physiopathology)
• Pilot Projects
• Prospective Studies
• Spinal Curvatures (drug therapy, physiopathology)
• Treatment Outcome