Camptocormia

Abnormal flexion of the thoracolumbar spine that is greater than 45 degrees anterior (forward bending). It often occurs in older individuals with neurlogic or muscular conditions such as AMYOTROPHIC LATERAL SCLEROSIS or PARKINSON DISEASE.

Also Known As:

Networked: 125 relevant articles (26 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinson Disease (Parkinson's Disease)
2.	Dystonia (Limb Dystonia)
3.	Parkinsonian Disorders (Parkinsonism)
4.	Congenital Abnormalities (Deformity)
5.	Multiple System Atrophy

Experts

1.	Margraf, Nils G: 5 articles (01/2022 - 04/2010)
2.	Murata, Miho: 4 articles (01/2016 - 08/2009)
3.	Colosimo, Carlo: 3 articles (01/2020 - 01/2009)
4.	Deuschl, Günther: 3 articles (03/2015 - 04/2010)
5.	Schulz-Schaeffer, Walter J: 3 articles (03/2015 - 04/2010)
6.	Wrede, Arne: 3 articles (03/2015 - 04/2010)
7.	Lai, Yijie: 2 articles (01/2021 - 01/2021)
8.	Li, Dianyou: 2 articles (01/2021 - 01/2021)
9.	Song, Yunhai: 2 articles (01/2021 - 01/2021)
10.	Sun, Bomin: 2 articles (01/2021 - 01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Camptocormia:

1.	Levodopa (L Dopa)FDA LinkGeneric 03/01/2015 - "All patients with duration of camptocormia up to 1.5 years showed a beneficial effect; patients between 1.5 and ∼3 years showed mixed results, but none with a duration of more than 40 months improved except for 1 patient whose camptocormia was levodopa responsive. " 01/05/2023 - "We then explored the efficacy of DBS for camptocormia by statistical analysis of the bending angle, the Unified Parkinson's Disease Rating Scale III (UPDRS-III) and L-dopa equivalent daily dose (LEDD), and by evaluating the prognosis after DBS. " 08/09/2005 - "Twelve patients received levodopa, with minimal or no improvement in the camptocormia. " 10/01/2021 - "Camptocormia in PD typically responds poorly to levodopa. " 01/01/2018 - "The following variables including the proportion of males; age; disease duration; total levodopa equivalent daily dosage; Unified PD Rating Scale (UPDRS) III score; Hoehn and Yahr stage; the percentages of festination, freezing of gait and falls; and the subscores (e.g., "problems having sex") and frequencies (e.g., "forget to do things") of the Non-Motor Symptoms Scale were significantly higher in patients with camptocormia compared to those variables in patients without camptocormia (P < 0.05). "
2.	Lidocaine (Xylocaine)FDA LinkGeneric 03/01/2013 - "In a previous study, we classified camptocormia into upper and lower types based on the inflection point, and reported that lidocaine injection into the external oblique muscle, but not into the internal oblique or rectus abdomen, improved upper camptocormia in PD. " 07/01/2015 - "Lidocaine was injected into the external oblique in patients with upper camptocormia and the psoas major in patients with lower camptocormia. " 07/01/2015 - "Posture was improved in 8 out of 9 patients with upper camptocormia, and 9 out of 11 patients with lower camptocormia following injections of lidocaine. " 03/01/2013 - "The study subjects were 12 patients with PD and upper camptocormia who were treated with repeated lidocaine injections into the bilateral external oblique followed by rehabilitation. " 07/01/2015 - "We previously classified camptocormia of Parkinson's disease (PD) into upper and lower types based on the inflection point, and reported improvement of upper camptocormia after lidocaine injection into the external oblique. "
3.	Botulinum Toxins (Botulinum Toxin)IBA 12/01/2018 - "Botulinum toxin (BT) may be beneficial, but data is scarce regarding the efficacy of administration of BT into the bilateral external oblique (EO) muscle for treatment of camptocormia in PD. " 10/01/2014 - "Improvement in dystonic camptocormia following botulinum toxin injection to the external oblique muscle." 12/01/2015 - "Treatment of camptocormia with botulinum toxin." 01/30/2009 - "Injection of the iliopsoas muscle with botulinum toxin in camptocormia." 04/30/2008 - "Ultrasound-guided injection of the iliopsoas muscle with botulinum toxin in camptocormia."
4.	Selegiline (E250)FDA LinkGeneric 01/01/2016 - "This study, an open trial, was aimed at assessing the efficacy of selegiline in the treatment of mild camptocormia in PD patients. " 01/01/2016 - "Treatment of Mild Camptocormia with Selegiline in Patients with Parkinson's Disease."
5.	levodopa drug combination carbidopa (Nakom)FDA LinkGeneric 08/03/2017 - "Wearing-off occurred when she was 57 years old, 3 years after starting carbidopa/levodopa, and truncal postural abnormalities-painful camptocormia with Pisa syndrome to the right-appeared at 58 years of age. " 10/01/2021 - "We observed that the addition of um-PEALut to acute treatment with carbidopa/levodopa resulted in improved dyskinesia and reduced camptocormia. " 10/01/2021 - "um-PEALut shows potential as an efficacious adjuvant therapy for patients with PD receiving carbidopa/levodopa to treat both dyskinesia and camptocormia in acute and chronic fashion." 09/01/2007 - "Adjustment of dopaminergic therapy (carbidopa-levodopa and entacapone) to minimize motor fluctuations and camptocormia."
6.	Type A Botulinum Toxins (Botox)FDA Link 04/30/2008 - "Here, we report on the ultrasound-guided ventral injection of botulinum toxin A (BTX) into deep portions of the iliopsoas muscle in four parkinsonian patients with camptocormia as chief complaint. " 08/09/2005 - "Nine patients received botulinum toxin type A injections into the rectus abdominus, with notable improvement in their camptocormia in four. "
7.	Therapeutic UsesIBA 03/01/2013 - "Our results showed that repeated lidocaine injections into the external oblique improved upper camptocormia, and that the effect was maintained in the majority of patients during the 90-day observation period, indicating that repeated lidocaine injections into the external oblique have therapeutic effect on upper camptocormia in patients with Parkinson's disease."
8.	Valproic Acid (Depakote)FDA LinkGeneric 07/01/1987 - "Camptocormia improved within a week after the reduction of the plasma valproate level to about 300 mumol/l. " 07/01/1987 - "Accordingly, camptocormia is a dose-dependent side effect of valproate." 07/01/1987 - "Four months later reversible camptocormia was manifested again concomitantly with about the same plasma valproate levels as above. " 07/01/1987 - "Camptocormia occurred concomitantly with an increase of the plasma valproate level from about 330 mumol/l up to 530 mumol/l. " 07/01/1987 - "Camptocormia, a new side effect of sodium valproate."
9.	Indicators and Reagents (Reagents)IBA 01/01/2022 - "The camptocormia angle has been established as a strong indicator for evaluating the progress of Parkinson's disease and the efficacy of therapeutical approaches. "
10.	levodopa drug combination benserazideIBA 12/01/2022 - "We report a rare case of camptocormia in a posthemorrhagic stroke patient whose rehabilitation progress was greatly impeded by this axial postural deformity and who responded well to Madopar treatment with an improvement in total camptocormia angle from 90 degrees to about 30 degrees, which translated to an improvement in physical function and reduction in care burden."

Therapies and Procedures

1.	Deep Brain Stimulation 11/01/2006 - "The camptocormia along with other parkinsonian symptoms improved dramatically after bilateral subthalamic deep brain stimulation." 01/01/2016 - "Case series suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) is effective in the acute but not the chronic stage of PD camptocormia. " 01/01/2011 - "Although deep brain stimulation was in some cases not effective against camptocormia, it is unclear in which types of patients it was effective in treating camptocormia. " 01/05/2023 - "In this review, we summarize the efficacy of deep brain stimulation (DBS) for camptocormia in PD. " 08/09/2005 - "One patient underwent bilateral subthalamic nucleus deep brain stimulation for PD, but there was no improvement in camptocormia. "
2.	Injections 07/01/2015 - "Posture was improved in 8 out of 9 patients with upper camptocormia, and 9 out of 11 patients with lower camptocormia following injections of lidocaine. " 08/09/2005 - "Nine patients received botulinum toxin type A injections into the rectus abdominus, with notable improvement in their camptocormia in four. " 03/01/2013 - "The study subjects were 12 patients with PD and upper camptocormia who were treated with repeated lidocaine injections into the bilateral external oblique followed by rehabilitation. " 06/01/2015 - "Camptocormia responds poorly to botulinum toxin injections, manipulation with dopaminergic treatment, and deep brain stimulation. " 06/01/2018 - "Finally, freezing of gait, camptocormia and Pisa syndrome in parkinsonism almost invariably fail to respond to botulinum toxin injections."
3.	Activities of Daily Living (ADL) 08/01/2017 - "Conservative treatment is effective in postural correction of camptocormia in Parkinson's disease, as well as improvement in ADL and motor symptoms." 01/01/2013 - "Abnormal posture (AP) is often seen in Parkinson's disease (PD), and marked forms known as dropped head syndrome and camptocormia encumber daily living activities. "
4.	Spinal Cord Stimulation 08/03/2017 - "Spinal cord stimulation (SCS) has recently been reported to be effective for truncal postural abnormalities such as camptocormia and Pisa syndrome in Parkinson's disease. " 08/03/2017 - "Effectiveness of spinal cord stimulation for painful camptocormia with Pisa syndrome in Parkinson's disease: a case report."
5.	Conservative Treatment 08/01/2017 - "To investigate the effect of a conservative treatment regime in Parkinson's disease patients with camptocormia. " 08/01/2017 - "Conservative treatment is effective in postural correction of camptocormia in Parkinson's disease, as well as improvement in ADL and motor symptoms."