Abstract | OBJECTIVE: METHODS: 192 obese KOA patients followed a 16 weeks weight loss intervention (ClinicalTrials.gov: NCT00655941). Serum Cartilage Oligomeric Matrix Protein (sCOMP), Urine C-terminal telopeptide of collagen type II (uCTX-II) and type I (uCTX-I) were determined by enzyme-linked immunoassay (ELISA) at baseline and after 16 weeks. Patient-reported symptoms were assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) Questionnaire without the sports and recreation score (KOOS-4). Change from baseline was analyzed using Analysis of CoVariance (ANCOVA) adjusting for sex, age, and body mass index (BMI). Bivariate associations were analyzed using Spearman's test of rank correlation. RESULTS: 175 patients completed the treatment and lost mean 13.4 (95% CI: 12.5-14.4) kg. sCOMP concentration decreased on average 1.1 (95% CI: -1.5 to -0.8) U/L with a correlation to weight loss (r = -0.17, P = 0.028), but not to change in KOOS-4 (r = -0.13, P = 0.091). uCTX-II increased significantly, mean 69 (95% CI: 31-106) ng/mmol creatinine, with no relation to weight loss (P = 0.14). Change in uCTX-II was reversely related to change in KOOS-4 (r = -0.28, P = 0.0003). uCTX-I increased, mean 67 (95% CI: 47-87) μg/mmol creatinine, and correlated to weight loss (r = 0.22, P = 0.0007), while not to KOOS-4 (P = 0.93). CONCLUSION: A rapid substantial weight loss in obese KOA patients was weakly, while significantly associated with a reduction in sCOMP, and increases in both uCTX-II and uCTX-I.
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Authors | E M Bartels, R Christensen, P Christensen, M Henriksen, A Bennett, H Gudbergsen, M Boesen, H Bliddal |
Journal | Osteoarthritis and cartilage
(Osteoarthritis Cartilage)
Vol. 22
Issue 11
Pg. 1817-25
(Nov 2014)
ISSN: 1522-9653 [Electronic] England |
PMID | 25106676
(Publication Type: Clinical Trial, Journal Article)
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Copyright | Copyright © 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Cartilage Oligomeric Matrix Protein
- Collagen Type II
- Creatinine
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Topics |
- Biomarkers
(blood)
- Body Mass Index
- Cartilage Oligomeric Matrix Protein
(blood)
- Collagen Type II
(blood)
- Creatinine
(blood)
- Female
- Follow-Up Studies
- Humans
- Knee Joint
- Male
- Middle Aged
- Obesity
(blood, complications)
- Osteoarthritis, Knee
(blood, etiology, rehabilitation)
- Prospective Studies
- Time Factors
- Treatment Outcome
- Weight Loss
(physiology)
- Weight Reduction Programs
(methods)
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