Abstract | OBJECTIVE:
Hormone therapy (HT) remains a mainstay of treatment of vasomotor symptoms, which are among the most common and most bothersome of menopausal symptoms. This review provides updates on HT and reviews newer menopausal therapies, focusing on recent safety data. METHODS: An interpretative review of recent medical literature was conducted using computerized databases. RESULTS: CONCLUSIONS: Recent studies suggest that HT has a neutral or even beneficial effect on coronary heart disease and cognition when used in the early postmenopausal years. The risk-to-benefit ratio of estrogen therapy in hysterectomized women is more favorable than that of estrogen- progestin regimens in nonhysterectomized women. Conjugated estrogens/ bazedoxifene now provides a progestin-free option for managing vasomotor symptoms in postmenopausal women with an intact uterus. Low-dose paroxetine may be an alternative for some women when hormonal treatments are contraindicated.
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Authors | Sebastian Mirkin, David F Archer, James H Pickar, Barry S Komm |
Journal | Menopause (New York, N.Y.)
(Menopause)
Vol. 22
Issue 3
Pg. 351-60
(Mar 2015)
ISSN: 1530-0374 [Electronic] United States |
PMID | 25051290
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Estrogen Replacement Therapy
(methods)
- Female
- Humans
- Menopause
(drug effects)
- Middle Aged
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