Abstract |
We describe a case of absence-like electrographic seizures during NREM sleep in a patient who was taking sodium oxybate, a sodium salt of γ-hydroxybutyric acid (GHB). An overnight full montage electroencephalography (EEG) study revealed numerous frontally predominant rhythmic 1.5-2 Hz sharp waves and spike-wave activity during stage N2 and N3 sleep at the peak dose time for sodium oxybate, resembling atypical absence-like electrographic seizures. The patient was later weaned off sodium oxybate, and a repeat study did not show any such electrographic seizures. Absence-like seizures induced by GHB had previously been described in experimental animal models. We present the first reported human case of absence-like electrographic seizure associated with sodium oxybate.
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Authors | Joseph Cheung, Brendan P Lucey, Stephen P Duntley, Rachel S Darken |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 10
Issue 7
Pg. 811-2
(Jul 15 2014)
ISSN: 1550-9397 [Electronic] United States |
PMID | 25024661
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anesthetics
- Hydroxybutyrates
- 4-hydroxybutyric acid
- Sodium Oxybate
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Topics |
- Adult
- Anesthetics
(adverse effects)
- Electroencephalography
(drug effects)
- Epilepsy, Absence
(chemically induced)
- Humans
- Hydroxybutyrates
(adverse effects)
- Male
- Sodium Oxybate
(adverse effects)
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