Abstract | INTRODUCTION:
Hyperhomocysteinemia (hyperHcy) is an important risk factor for atherosclerosis, which is currently a major cause of death in renal transplant patients (RTRs). The aim of this study was to determine the associated factors of hyperHcy in RTRs in northern Iran. METHODS: RESULTS: In this analytic cross-sectional study the prevalence of hyperHcy was 70.3%. Hyperhomocysteinemia was defined as total serum homocysteine of 12 μmol/L or greater. The comparison of the group of 44 patients with tHcy level less than 12 and the group of 104 patients with tHcy level of 12 μmol/L or greater revealed that those subjects with hyperHcy were mostly younger, male, with lower BMI, history of glomerulonephritis, higher serum level of uric acid, and blood cyclosporine trough level (C0) and used higher doses of cyclosporine A. Significant correlation was found between tHcy level and recipients age, serum creatinine, BUN, folate concentrations, and creatinine clearance. However, multivariate analysis indicated that serum folate (P=0.01), vitamin B12 (P=0.05), creatinine (P=0.03), and BUN (P=0.05), and blood cyclosporine trough level (C0, P=0.005) were independently associated with tHcy levels. CONCLUSION:
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Authors | Ali Monfared, Seyyede Zeinab Azimi, Ehsan Kazemnezhad, Masoud Khosravi, Mohammadkazem Lebadi, Ebrahim Mirzajani, Mohammad Najafi Ashtiani |
Journal | Transplantation
(Transplantation)
Vol. 98
Issue 1
Pg. 66-71
(Jul 15 2014)
ISSN: 1534-6080 [Electronic] United States |
PMID | 24978036
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Immunosuppressive Agents
- Homocysteine
- Cyclosporine
- Folic Acid
- Creatinine
- Vitamin B 12
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Topics |
- Adult
- Biomarkers
(blood)
- Blood Urea Nitrogen
- Chi-Square Distribution
- Creatinine
(blood)
- Cross-Sectional Studies
- Cyclosporine
(blood, therapeutic use)
- Female
- Folic Acid
(blood)
- Homocysteine
(blood)
- Humans
- Hyperhomocysteinemia
(blood, diagnosis, epidemiology)
- Immunosuppressive Agents
(blood, therapeutic use)
- Iran
(epidemiology)
- Kidney Failure, Chronic
(blood, diagnosis, epidemiology, surgery)
- Kidney Transplantation
- Linear Models
- Male
- Middle Aged
- Multivariate Analysis
- Prevalence
- Risk Factors
- Time Factors
- Vitamin B 12
(blood)
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