Metalloproteinases in hypertension and cardiac disease: differential expression and mutual regulation.

Abstract

Arterial hypertension, a condition characterized by sustained elevated blood pressure, is associated with pathological cardiac remodeling (i.e. cardiac hypertrophy and fibrosis) and is a major risk factor for cardiac failure. These processes can be triggered by excess vasoconstrictive agonists, which induce metalloproteinase-dependent shedding of growth factors to transactivate growth factor receptors and initiate disease signaling. Here, we review emerging evidence that agonist-activated metalloproteinases exhibit different expression patterns and mutual transcriptional regulation during the development of hypertension and cardiac remodeling.

• Authors: Ana-Maria Bosonea, Xiang Wang, Jeffrey Odenbach, Carlos Fernandez-Patron
• Journal: Drug discovery today. Disease models (Drug Discov Today Dis Models) Vol. 8 Issue 1 Pg. 29-35 ( 2011) ISSN: 1740-6757 [Print] Netherlands
• PMID: 24976847 (Publication Type: Journal Article)