Abstract | OBJECTIVE: METHODS: 60 patients undergoing gastric cancer surgery were equally randomized into two groups. They received post-operative patient-controlled intravenous (IV) analgesia using morphine either with or without flurbiprofen. Visual analogue scale (VAS) scores, Bruggemann comfort scale (BCS) scores, morphine consumption, time of first flatus, incidence of nausea/ vomiting, and T-lymphocyte subsets (CD3⁺, CD4⁺, and CD8⁺) and natural killer cells (CD3⁻CD16⁺CD56⁺) were evaluated. RESULTS: No significant difference was observed in the VAS scores, BCS scores, and nausea/ vomiting incidence between groups. Less morphine was consumed and the time of first flatus was earlier in patients receiving morphine with flurbiprofen than morphine alone. The expression of CD3⁺, CD4⁺, CD4⁺/CD8⁺, and CD3⁻CD16⁺CD56⁺ decreased at 2 hours after incision and, except for CD3⁻CD16⁺CD56⁺, returned to baseline at 120 hours after surgery. Moreover, the expression of CD3⁻CD16⁺CD56⁺ at 2 hours after incision and the expression of CD3⁺, CD4⁺, CD4⁺/CD8⁺, and CD3⁻CD16⁺CD56⁺ at 24 hours after surgery were higher in patients receiving morphine with flurbiprofen than morphine alone. CONCLUSION:
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Authors | Jin-Chun Shen, He-Liang Sun, Ming-Qiang Zhang, Xiao-Yu Liu, Zhong- Yun Wang, Jian-Jun Yang |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 52
Issue 8
Pg. 669-75
(Aug 2014)
ISSN: 0946-1965 [Print] Germany |
PMID | 24755130
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Anti-Inflammatory Agents, Non-Steroidal
- Flurbiprofen
- Morphine
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Topics |
- Adult
- Aged
- Analgesia, Patient-Controlled
(adverse effects, methods)
- Analgesics, Opioid
(administration & dosage, adverse effects)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, pharmacology)
- Double-Blind Method
- Female
- Flurbiprofen
(administration & dosage, pharmacology)
- Humans
- Killer Cells, Natural
(drug effects, pathology)
- Male
- Middle Aged
- Morphine
(administration & dosage, adverse effects)
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Stomach Neoplasms
(surgery)
- T-Lymphocyte Subsets
(drug effects, pathology)
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