Abstract | BACKGROUND: METHODS: Individuals aged 30-79 years (n = 5,151) were classified into 6 groups according to LDL-C levels (<140 and ≥140mg/dL or lipid medication) and BP levels (optimal BP, prehypertension, and hypertension; reference: low LDL-C and optimal BP). Hazard ratios (HRs) were calculated after adjusting for age, high-density lipoprotein cholesterol, diabetes, smoking status, and alcohol consumption. The effect modification of LDL-C on BP-CVD association was assessed using likelihood ratio tests. RESULTS: CONCLUSIONS: The HRs for CAD in prehypertensive and hypertensive groups were higher than those in the optimal BP group at the same LDL-C levels in a Japanese population; however, there was no statistical effect modification of LDL-C on the BP-CAD association.
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Authors | Rumi Tsukinoki, Tomonori Okamura, Makoto Watanabe, Yoshihiro Kokubo, Aya Higashiyama, Kunihiro Nishimura, Misa Takegami, Yoshitaka Murakami, Akira Okayama, Yoshihiro Miyamoto |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 27
Issue 11
Pg. 1362-9
(Nov 2014)
ISSN: 1941-7225 [Electronic] United States |
PMID | 24713850
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: [email protected]. |
Chemical References |
- Biomarkers
- Cholesterol, LDL
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Topics |
- Adult
- Aged
- Asian People
- Biomarkers
(blood)
- Blood Pressure
- Brain Ischemia
(blood, diagnosis, ethnology, physiopathology)
- Chi-Square Distribution
- Cholesterol, LDL
(blood)
- Coronary Artery Disease
(blood, diagnosis, ethnology, physiopathology)
- Dyslipidemias
(blood, diagnosis, ethnology)
- Female
- Health Surveys
- Humans
- Hypertension
(diagnosis, ethnology, physiopathology)
- Incidence
- Japan
(epidemiology)
- Life Style
(ethnology)
- Likelihood Functions
- Male
- Middle Aged
- Odds Ratio
- Prehypertension
(ethnology, physiopathology)
- Proportional Hazards Models
- Risk Factors
- Stroke
(blood, diagnosis, ethnology, physiopathology)
- Time Factors
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