Abstract | PURPOSE: PATIENTS AND METHODS: Thirty-two patients with gastric or gastroesophageal junction cancer were enrolled in this study after undergoing radical resection. The patients received the following chemotherapy: docetaxel (60 mg/m(2)) on day 1, cisplatin (12 mg/m(2) per day) on days 1 to 5, and 5-FU (2500 mg/m(2)) continuous infusion for 120 hours, repeated every 3 weeks for six cycles. The primary end point was disease-free survival (DFS). RESULTS: The median DFS was 17.0 months. The 1-year DFS was 72%, and the 2-year DFS was 37.5%. The median overall survival was 28.0 months. Using univariate analysis, the technique of lymph node dissection was a predictor for postoperative relapse. The median DFS was 15.0 months in the D1 group and 18.0 months in the D2 group (P = .043). The most frequent grade 3/4 adverse events were neutropenia (56.25%), diarrhea (9.38%), nausea (6.25%), and vomiting (6.25%); 12.5% of patients developed febrile neutropenia. There were no chemotherapy-related deaths. CONCLUSIONS:
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Authors | Changting Meng, Hongyan Yin, Zhao Sun, Jianfeng Zhou, Shuchang Chen, Chunmei Bai, Lin Zhao |
Journal | Translational oncology
(Transl Oncol)
Vol. 7
Issue 2
Pg. 277-83
(Apr 2014)
ISSN: 1936-5233 [Print] United States |
PMID | 24704535
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Neoplasia Press, Inc. Published by Elsevier Inc. All rights reserved. |