Abstract | AIM: METHODS: Data are from youth ≥ 10 years old with clinically diagnosed T1D for ≥ 3 months and ≥ 1 positive diabetes autoantibody in the SEARCH for Diabetes in Youth Study. Fiber intake was assessed by food frequency questionnaire with measurement error (ME) accounted for by structural sub-models derived using additional 24-h dietary recall data in a calibration sample and the respective exposure-disease model covariates. Markers of inflammation, measured at baseline, included IL-6 (n=1405), CRP (n=1387), and fibrinogen (n=1340); markers of arterial stiffness, measured approximately 19 months post-baseline, were available in a subset of participants and included augmentation index (n=180), pulse wave velocity (n=184), and brachial distensibility (n=177). RESULTS: Mean (SD) T1D duration was 47.9 (43.2) months; 12.5% of participants were obese. Mean (SD) ME-adjusted fiber intake was 15 (2.8) g/day. In multivariable analyses, fiber intake was not associated with inflammation or arterial stiffness. CONCLUSION: Among youth with T1D, fiber intake does not meet recommendations and is not associated with measures of systemic inflammation or vascular stiffness. Further research is needed to evaluate whether fiber is associated with these outcomes in older individuals with T1D or among individuals with higher intakes than those observed in the present study.
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Authors | Lindsay M Jaacks, Jamie Crandell, Angela D Liese, Archana P Lamichhane, Ronny A Bell, Dana Dabelea, Ralph B D'Agostino Jr, Lawrence M Dolan, Santica Marcovina, Kristi Reynolds, Amy S Shah, Elaine M Urbina, R Paul Wadwa, Elizabeth J Mayer-Davis |
Journal | Journal of diabetes and its complications
(J Diabetes Complications)
2014 May-Jun
Vol. 28
Issue 3
Pg. 305-10
ISSN: 1873-460X [Electronic] United States |
PMID | 24613131
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Dietary Fiber
- Fibrinogen
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Topics |
- Adolescent
- Age Factors
- Biomarkers
(metabolism)
- Child
- Cohort Studies
- Diabetes Mellitus, Type 1
(physiopathology)
- Dietary Fiber
(pharmacology)
- Female
- Fibrinogen
(metabolism)
- Humans
- Inflammation
(physiopathology)
- Linear Models
- Male
- Pulse Wave Analysis
- Retrospective Studies
- United States
- Vascular Stiffness
(drug effects, physiology)
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