Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy.

Abstract

Sulodexide is a mixed glycosaminoglycan composed of heparin and dermatan sulfate. In this study, the anti-angiogenic effect of sulodexide was investigated using an oxygen-induced retinopathy (OIR) mouse model. The retinas of sham-injected OIR mice (P17) had a distinctive central area of nonperfusion, and this area was significantly decreased in sulodexide-injected mice. The number of neovascular tufts measured by SWIFT_NV and mean neovascular lumen number were significantly decreased in sulodexide-injected mice. Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed. Our results clearly demonstrate the anti-angiogenic effect of sulodexide and highlight sulodexide as a candidate supplementary substance to be used for the treatment of ocular pathologies that involve neovascularization.

• Authors: Hyoung Jo, Sang Hoon Jung, Jun Kang, Hye Bin Yim, Kui Dong Kang
• Journal: BMB reports (BMB Rep) Vol. 47 Issue 11 Pg. 637-42 (Nov 2014) ISSN: 1976-670X [Electronic] Korea (South)
• PMID: 24602608 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Glycosaminoglycans
• Vascular Endothelial Growth Factor A
• glucuronyl glucosamine glycan sulfate
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9
• Fluorescein-5-isothiocyanate
• Oxygen

Topics

• Angiogenesis Inhibitors (pharmacology, therapeutic use)
• Animals
• Disease Models, Animal
• Female
• Fluorescein-5-isothiocyanate (chemistry, metabolism)
• Glycosaminoglycans (pharmacology, therapeutic use)
• Male
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Mice
• Mice, Inbred ICR
• Oxygen (toxicity)
• Retina (drug effects, metabolism, pathology)
• Retinal Diseases (chemically induced, therapy)
• Retinal Neovascularization (pathology)
• Vascular Endothelial Growth Factor A (metabolism)