Immunotoxins for leukemia.

Abstract

Unconjugated monoclonal antibodies that target hematopoietic differentiation antigens have been developed to treat hematologic malignancies. Although some of these have activity against chronic lymphocytic leukemia and hairy cell leukemia, in general, monoclonal antibodies have limited efficacy as single agents in the treatment of leukemia. To increase their potency, the binding domains of monoclonal antibodies can be attached to protein toxins. Such compounds, termed immunotoxins, are delivered to the interior of leukemia cells based on antibody specificity for cell surface target antigens. Recombinant immunotoxins have been shown to be highly cytotoxic to leukemic blasts in vitro, in xenograft model systems, and in early-phase clinical trials in humans. These agents will likely play an increasing role in the treatment of leukemia.

• Authors: Alan S Wayne, David J Fitzgerald, Robert J Kreitman, Ira Pastan
• Journal: Blood (Blood) Vol. 123 Issue 16 Pg. 2470-7 (Apr 17 2014) ISSN: 1528-0020 [Electronic] United States
• PMID: 24578503 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antigens, CD19
• Immunotoxins
• Sialic Acid Binding Ig-like Lectin 2

Topics

• Animals
• Antigens, CD19 (metabolism)
• Clinical Trials as Topic
• Humans
• Immunotherapy (methods)
• Immunotoxins (chemistry, therapeutic use)
• Leukemia (immunology, therapy)
• Models, Molecular
• Molecular Targeted Therapy
• Sialic Acid Binding Ig-like Lectin 2 (antagonists & inhibitors)