Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes.

Abstract

HYPOTHESIS:

Decreased insulin sensitivity (IS) exists in type 1 diabetes. Serum uric acid (SUA), whose concentration is related to renal clearance, predicts vascular complications in type 1 diabetes. SUA is also inversely associated with IS in non-diabetics, but has not been examined in type 1 diabetes. We hypothesized SUA would be associated with reduced IS in adolescents and adults with type 1 diabetes.

METHODS:

The cross-sectional and longitudinal associations of SUA with IS were investigated in 254 adolescents with type 1 diabetes and 70 without in the Determinants of Macrovascular Disease in Adolescents with Type 1 Diabetes Study, and in 471 adults with type 1 diabetes and 571 without in the Coronary Artery Calcification in Type 1 diabetes (CACTI) study.

RESULTS:

SUA was lower in subjects with type 1 diabetes (p<0.0001), but still remained inversely associated with IS after multivariable adjustments in adolescents (β±SE: -1.99±0.62, p=0.001, R2 =2%) and adults (β±SE: -0.91±0.33, p=0.006, R2 = 6%) with type 1 diabetes, though less strongly than in non-diabetic controls (adolescents: β±SE: -2.70±1.19, p=0.03, R2 = 15%, adults: β±SE: -5.99±0.75, p<0.0001, R2 =39%).

CONCLUSION:

We demonstrated a significantly weaker relationship between SUA and reduced IS in subjects with type 1 diabetes than non-diabetic controls.

• Authors: Petter Bjornstad, Janet K Snell-Bergeon, Kimberly McFann, R Paul Wadwa, Marian Rewers, Christopher J Rivard, Diana Jalal, Michel B Chonchol, Richard J Johnson, David M Maahs
• Journal: Journal of diabetes and its complications (J Diabetes Complications) 2014 May-Jun Vol. 28 Issue 3 Pg. 298-304 ISSN: 1873-460X [Electronic] United States
• PMID: 24461546 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Uric Acid

Topics

• Adolescent
• Adult
• Age Factors
• Case-Control Studies
• Child
• Cross-Sectional Studies
• Diabetes Mellitus, Type 1 (blood, complications, physiopathology)
• Female
• Humans
• Incidence
• Insulin Resistance (physiology)
• Longitudinal Studies
• Male
• Middle Aged
• Risk Factors
• Uric Acid (blood)
• Vascular Diseases (epidemiology, etiology)
• Young Adult