Abstract | BACKGROUND: AIM: To determine the proportion of CHB patients with ALT ≤ 40 IU/L and liver fibrosis stage ≥ 2. Secondary goals include subgroup analysis by hepatitis B e antigen ( HBeAg) status, high hepatitis B virus (HBV) DNA levels, Asian ethnicity, lower ULN of ≤ 30 IU/L (males) and 19 IU/L (females), and advanced age. METHODS: Studies identified in EMBASE and MEDLINE (1/1990-6/2012) using the search criteria: " Hepatitis B"[Mesh] OR "Hepatitis B virus"[Mesh] OR " Hepatitis B, Chronic"[Mesh])) AND " Alanine Transaminase"[Mesh]) and abstracts containing the term ' hepatitis' from recent major U.S. gastroenterology and liver society meetings were considered. RESULTS: Among nine studies (N = 830 patients), a significant proportion (20.7%; 95% CI: 16.2-26.0%) of CHB patients with ALT levels ≤ 40 IU/L had significant fibrosis irrespective of HBeAg status, high HBV DNA levels, ethnicity or age, although this proportion may be higher in patients older than 30-40 years old. The corresponding proportion was 27.8% even when the newer ULN of 30 IU/L (males) and 19 IU/L (females) was applied. CONCLUSIONS: Approximately one fifth of CHB patients with ALT ≤ 40 IU/L may have significant hepatic fibrosis. The approach to such patients should be individualised, as further evaluation and treatment may be appropriate.
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Authors | D T Chao, J K Lim, W S Ayoub, L H Nguyen, M H Nguyen |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 39
Issue 4
Pg. 349-58
(Feb 2014)
ISSN: 1365-2036 [Electronic] England |
PMID | 24387289
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | © 2014 John Wiley & Sons Ltd. |
Chemical References |
- DNA, Viral
- Hepatitis B e Antigens
- Alanine Transaminase
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Topics |
- Adult
- Alanine Transaminase
(blood)
- DNA, Viral
(blood)
- Female
- Hepatitis B e Antigens
(blood)
- Hepatitis B virus
(isolation & purification)
- Hepatitis B, Chronic
(complications, physiopathology)
- Humans
- Liver Cirrhosis
(epidemiology, etiology)
- Male
- Middle Aged
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