Therapeutic value of combined therapy with deferasirox and silymarin on iron overload in children with Beta thalassemia.

Abstract

BACKGROUND:

Beta thalassemia is an inherited hemoglobin disorder resulting in a severe, chronic anemia requiring life-long blood transfusion that induces iron overload. Silymarin is a flavonoid complex isolated from Silybin marianum with a strong antioxidant activity, inducing an hepatoprotective action, and probably, a protective effect on iron overload. The aim of this work was to determine the silymarin value in improving iron chelation in thalassemic patients with iron overload treated with Deferasirox.

PATIENTS AND METHODS:

This study was conducted on 40 children with beta thalassemia major under follow-up at Hematology Unit, Pediatric Department, Tanta University Hospital with serum ferritin level more than 1000 ng/ml and was divided into two groups. Group IA: Received oral Deferasirox (Exjade) and silymarin for 6 months. Group IB: Received oral Deferasirox (Exjade) and placebo for 6 months and 20 healthy children serving as a control group in the period between April 2011 and August 2012 and was performed after approval from research ethical committee center in Tanta University Hospital and obtaining an informed written parental consent from all participants in this study.

RESULTS:

Serum ferritin levels were markedly decreased in group IA cases compared with group IB (P= 0.001).

CONCLUSION:

From this study we concluded that, silymarin in combination with Exjade can be safely used in the treatment of iron-loaded thalassemic patients as it showed good iron chelation with no sign of toxicity.

RECOMMENDATIONS:

We recommend extensive multicenter studies in a large number of patients with longer duration of follow-up and more advanced techniques of assessment of iron status in order to clarify the exact role of silymarin in reducing iron overload in children with beta thalassemia.

• Authors: Adel A Hagag, Mohamed S Elfrargy, Rana A Gazar, Aml Ezzat Abd El-Lateef
• Journal: Mediterranean journal of hematology and infectious diseases (Mediterr J Hematol Infect Dis) Vol. 5 Issue 1 Pg. e2013065 ( 2013) ISSN: 2035-3006 [Print] Italy
• PMID: 24363880 (Publication Type: Journal Article)