Abstract | BACKGROUND: STUDY DESIGN: Cross-sectional study. SETTING & PARTICIPANTS: PREDICTOR: OUTCOMES: Plasma PCSK9 concentration. MEASUREMENTS: RESULTS: Mean serum total and LDL cholesterol levels in patients with nephrotic syndrome (317.9±104.2 [SD] and 205.9±91.1mg/dL) and PD patients (200.0±27.6 and 126.7±18.5mg/dL) were significantly (P<0.05) higher than in hemodialysis patients (140.9±22.9 and 79.1±19.5mg/dL) and the control group (166.5±26.5 and 95.9±25.2mg/dL). This was associated with significantly (P<0.05) higher plasma PCSK9 levels in patients with nephrotic syndrome (15.13±4.99ng/mL) and PD patients (13.30±1.40ng/mL) than in the control (9.19±0.60ng/mL) and hemodialysis (7.30±0.50ng/mL) groups. Plasma PCSK9 level was directly related to total and LDL cholesterol concentrations in the study population (r=0.559 [P<0.001] and r=0.497 [P<0.001], respectively). LIMITATIONS: Small number of participants may limit generalizability. CONCLUSIONS:
Nephrotic syndrome and PD are associated with higher plasma PCSK9 concentration, which can contribute to elevation of LDL levels by promoting LDLR deficiency.
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Authors | Kyubok Jin, Bong-Soo Park, Yang-Wook Kim, Nosratola D Vaziri |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 63
Issue 4
Pg. 584-9
(Apr 2014)
ISSN: 1523-6838 [Electronic] United States |
PMID | 24315769
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Cholesterol, LDL
- Cholesterol
- PCSK9 protein, human
- Proprotein Convertase 9
- Proprotein Convertases
- Serine Endopeptidases
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Topics |
- Adult
- Apoptosis
(physiology)
- Cholesterol
(blood)
- Cholesterol, LDL
(blood)
- Comorbidity
- Cross-Sectional Studies
- Female
- Humans
- Hypercholesterolemia
(blood, epidemiology, prevention & control)
- Male
- Middle Aged
- Nephrotic Syndrome
(blood, epidemiology, therapy)
- Peritoneal Dialysis
- Proprotein Convertase 9
- Proprotein Convertases
(blood)
- Renal Dialysis
- Serine Endopeptidases
(blood)
- Young Adult
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