Abstract |
Chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL) cells typically have low 2-deoxy-2-[(18)F]fluoro- d-glucose (FDG) avidity, and patients with CLL have an increased risk of developing FDG-avid aggressive lymphomas, second malignancies and infections. We hypothesized that FDG positron emission tomography-computed tomography (PET-CT) of the trunk is a sensitive method of detecting these complications in patients with CLL. Of the of 2299 patients with CLL seen in the Division of Hematology at Mayo Clinic Rochester between 1 January 2006 and 31 December 2011, 272 (11.8%) had 526 PET-CT scans and 472 (89.7%) of these were reported as abnormal. Among the 293 (55.7%) PET-CT scans used for routine evaluation of CLL, the PET component was of clinical value in only one instance. In contrast, in 83 (30.5%) patients, PET-CT scans used to evaluate new clinical complications localized high FDG-avidity lesions for biopsies. This resulted in clinically relevant new diagnoses in 32 patients, including those with more aggressive lymphoma (n = 16), non- hematological malignancies (n = 8) and opportunistic infections (n = 3). Twenty-seven patients had high FDG-avidity CLL, which was associated with prominent lymph node proliferation centers, an increased frequency of poor prognostic factors (17p13 deletion, unmutated immunoglobulin heavy chain variable gene [IGHV], expression of ZAP-70 and CD38) and a shorter overall survival. We conclude that FDG PET scans should not be used for routine surveillance of patients with CLL. However PET-CT scans are sensitive, but not specific, for detection of aggressive lymphomas, other cancers and systemic infections in patients with CLL.
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Authors | Michael J Conte, Deborah A Bowen, Gregory A Wiseman, Kari G Rabe, Susan L Slager, Susan M Schwager, Timothy G Call, David S Viswanatha, Clive S Zent |
Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 55
Issue 9
Pg. 2079-84
(Sep 2014)
ISSN: 1029-2403 [Electronic] United States |
PMID | 24286263
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin Heavy Chains
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biopsy
- Chromosome Aberrations
- Disease Management
- Female
- Fluorodeoxyglucose F18
- Humans
- Immunoglobulin Heavy Chains
(genetics)
- Immunophenotyping
- Infections
(diagnosis, etiology)
- Leukemia, Lymphocytic, Chronic, B-Cell
(complications, diagnosis, genetics)
- Lymph Nodes
(pathology)
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Neoplasms, Second Primary
(diagnosis, etiology)
- Positron-Emission Tomography
- Prognosis
- Tomography, X-Ray Computed
- Young Adult
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